INT187789

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 16.18
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 9
plaque 3
lumen 2
cleavage 2
astrocytes 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 105 99.98 Very High Very High Very High
glial activation 25 99.68 Very High Very High Very High
Inflammation 223 96.72 Very High Very High Very High
Nav1.6 15 86.44 High High
agonist 34 81.64 Quite High
cINOD 85 79.92 Quite High
Inflammatory marker 4 79.24 Quite High
Nerve growth factor 7 79.16 Quite High
antagonist 26 77.48 Quite High
sodium channel 63 77.00 Quite High
Disease Link Frequency Relevance Heat
Disease 1306 100.00 Very High Very High Very High
Convulsion 100 100.00 Very High Very High Very High
Cv Unclassified Under Development 88 99.98 Very High Very High Very High
Apoptosis 217 99.88 Very High Very High Very High
Transient Ischemic Attack 17 99.78 Very High Very High Very High
Amyloid Plaque 203 99.44 Very High Very High Very High
Stroke 64 98.52 Very High Very High Very High
Disease Progression 37 98.48 Very High Very High Very High
Targeted Disruption 655 98.20 Very High Very High Very High
Absence Epilepsy 11 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While other post-translational mechanisms may account for this observed decrease in GGA3, it is tempting to speculate that apoptotic events may play a role in the increase in BACE1 in AD brain, indeed, elevated BACE1 activity may lead to increased A?
Positive_regulation (increased) of Positive_regulation (elevated) of BACE1 in brain associated with disease and apoptosis
1) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.86 Pain Relevance 0.03
While other post-translational mechanisms may account for this observed decrease in GGA3, it is tempting to speculate that apoptotic events may play a role in the increase in BACE1 in AD brain, Indeed, elevated BACE1 activity may lead to increased A?
Positive_regulation (increased) of Positive_regulation (elevated) of BACE1 in brain associated with apoptosis
2) Confidence 0.49 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.53 Pain Relevance 0.03
plays an important role in mediating the post-transcriptional upregulation of BACE1 in human AD and 5XFAD mouse brains [32], [33].
Positive_regulation (mediating) of Positive_regulation (upregulation) of BACE1 in brains associated with disease
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.78 Pain Relevance 0.04
Paradoxically, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [69, 143, 199], implying that a post-transcriptional mechanism may be responsible for the BACE1 increase.
Positive_regulation (responsible) of Positive_regulation (increase) of BACE1 in brain associated with targeted disruption and amyloid plaque
4) Confidence 0.46 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.02 Pain Relevance 0.33
Caspase cleavage of GGA3 during apoptosis also caused BACE1 levels to increase, suggesting a potential mechanism for BACE1 elevation.
Positive_regulation (caused) of Positive_regulation (increase) of BACE1 in cleavage associated with apoptosis
5) Confidence 0.46 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.10 Pain Relevance 0
Indeed, whether increased BACE1 activity is sufficient to induce AD pathogenesis, and the initial cause (s) of the BACE1 elevation remains unknown.
Positive_regulation (sufficient) of Spec (whether) Positive_regulation (increased) of BACE1
6) Confidence 0.46 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.85 Pain Relevance 0.09
In an experimental stroke model used to study the effects of transient cerebral ischemia, ischemia led to an elevation in BACE1 protein and activity, and BACE1 immunoreactivity was strongly associated with TUNEL staining, a marker of apoptosis [229].
Positive_regulation (led) of Positive_regulation (elevation) of BACE1 protein associated with transient ischemic attack, stroke, ischemia and apoptosis
7) Confidence 0.46 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.42 Pain Relevance 0.18
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Positive_regulation (responsible) of in plaques Positive_regulation (increase) of BACE1 in brain associated with targeted disruption and amyloid plaque
8) Confidence 0.46 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.31 Pain Relevance 0.16
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

Background

Positive_regulation (increased) of Positive_regulation (activation) of BACE1 in plaque associated with targeted disruption, amyloid plaque and glial activation
9) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Title Doc Link PMC1274341 Disease Relevance 1.20 Pain Relevance 0.28
In situ fluorescence detection of BACE1 activity revealed that sites of increased BACE1 activation colocalised to GFAP positive and activated astrocytes (Figure 4C).
Positive_regulation (increased) of Positive_regulation (activation) of BACE1 in astrocytes
10) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 0.31 Pain Relevance 0.11
Increased severity of KA-induced seizures in BACE1-/- mice
Positive_regulation (Increased) of Positive_regulation (induced) of BACE1 associated with convulsion
11) Confidence 0.44 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 1.09 Pain Relevance 0.11
It is currently unclear whether the BACE1 elevation in AD promotes A?
Spec (whether) Positive_regulation (promotes) of Spec (whether) Positive_regulation (elevation) of BACE1 associated with disease
12) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.37 Pain Relevance 0
Indeed, whether the BACE1 elevation in AD promotes A?
Positive_regulation (promotes) of Spec (whether) Positive_regulation (elevation) of BACE1
13) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.45 Pain Relevance 0
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (results) of Positive_regulation (accumulation) of BACE1 associated with apoptosis
14) Confidence 0.40 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.80 Pain Relevance 0.04
Furthermore, RNAi silencing of GGA3 caused an increase in the level and activity of BACE1 as determined by elevations in C99 and A?.
Positive_regulation (caused) of Positive_regulation (increase) of BACE1
15) Confidence 0.40 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.91 Pain Relevance 0.08
Indeed the Puglielli group have just reported that ceremide stimulates the carrier-mediated translocation of acety-CoA into the lumen of the ER, a prerequisite for the lysine acetylation of BACE1 (detailed previously) that is necessary for BACE1 maturation and stabilization [92].
Positive_regulation (necessary) of Positive_regulation (stabilization) of BACE1 in lumen
16) Confidence 0.40 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.88 Pain Relevance 0.16
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (results) of Positive_regulation (stabilization) of BACE1 associated with apoptosis
17) Confidence 0.40 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.80 Pain Relevance 0.04
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (results) of Positive_regulation (stabilization) of BACE1 associated with apoptosis
18) Confidence 0.40 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.60 Pain Relevance 0.04
Thus, Tesco and colleagues suggested that apoptosis, caused by ischemic events, drives GGA3 depletion and results in the stabilization and accumulation of BACE1 leading to elevated enzymatic activity.
Positive_regulation (results) of Positive_regulation (accumulation) of BACE1 associated with apoptosis
19) Confidence 0.40 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.60 Pain Relevance 0.04
It is plausible that different factors cause elevations in BACE1 levels and activity at different stages of the disease.
Positive_regulation (cause) of Positive_regulation (elevations) of BACE1 associated with disease
20) Confidence 0.40 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.59 Pain Relevance 0.06

General Comments

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