INT18779

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.01
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 2
colon 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 57 100.00 Very High Very High Very High
anesthesia 1 64.16 Quite High
Disease Link Frequency Relevance Heat
Nephrotoxicity 3 94.08 High High
Hepatotoxicity 2 90.96 High High
Colon Cancer 1 89.84 High High
Liver Cancer 1 84.64 Quite High
Toxicity 5 75.00 Quite High
Hepatocellular Cancer 2 72.72 Quite High
Cancer 1 70.64 Quite High
Necrosis 2 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Castration also reduced the level of selective covalent binding of APAP metabolites to renal proteins as detected on Western blots with affinity-purified anti-APAP antibodies.
Negative_regulation (reduced) of APAP Binding (binding) of associated with paracetamol
1) Confidence 0.41 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.38 Pain Relevance 1.41
APAP binding peaked at 3 hr and did not decrease significantly thereafter.
Neg (not) Negative_regulation (decrease) of APAP Binding (binding) of associated with paracetamol
2) Confidence 0.36 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981734 Disease Relevance 0 Pain Relevance 0.77
The formation of the APAP adducts could be inhibited by the same agents which prevent APAP cytotoxicity.
Negative_regulation (inhibited) of APAP Binding (formation) of associated with paracetamol
3) Confidence 0.32 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791125 Disease Relevance 0.21 Pain Relevance 1.21
Likewise, with APAP in colon anticarcinogenicity, at 1000 ppm it reduced DNA binding and exerted a cytoprotective effect against DMAB.
Negative_regulation (reduced) of APAP Binding (binding) of in colon associated with paracetamol
4) Confidence 0.06 Published 2002 Journal Eur. J. Cancer Prev. Section Abstract Doc Link 12570342 Disease Relevance 0.25 Pain Relevance 0.40
In acetone-pretreated mice, the 150 and 400 mg/kg APAP doses caused similar depletion of CYP2E1 activity and similar levels of covalent binding of APAP to liver proteins.
Negative_regulation (depletion) of APAP Binding (binding) of in liver associated with paracetamol
5) Confidence 0.01 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.95

General Comments

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