INT1878

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1976
Last Reported 2011
Negated 14
Speculated 21
Reported most in Abstract
Documents 440
Total Number 462
Disease Relevance 321.16
Pain Relevance 127.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
T cells 26
anterior 15
Reiter 13
leukocyte 9
B35 8
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 2396 100.00 Very High Very High Very High
Arthritis 1250 100.00 Very High Very High Very High
spondylitis 164 100.00 Very High Very High Very High
Crohn's disease 31 100.00 Very High Very High Very High
Inflammation 516 99.80 Very High Very High Very High
rheumatoid arthritis 302 99.74 Very High Very High Very High
Pain 256 99.72 Very High Very High Very High
cINOD 108 99.64 Very High Very High Very High
psoriasis 57 99.04 Very High Very High Very High
methotrexate 231 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 2636 100.00 Very High Very High Very High
Low Back Pain 2028 100.00 Very High Very High Very High
Seronegative Spondarthritis 1426 100.00 Very High Very High Very High
Chlamydia Infection 1093 100.00 Very High Very High Very High
Arthritis 529 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 495 100.00 Very High Very High Very High
Thyroiditis 254 100.00 Very High Very High Very High
Rheumatic Diseases 114 100.00 Very High Very High Very High
Sacroiliitis 98 100.00 Very High Very High Very High
Fever 44 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, this is the first report of the association of the HLA-B*1301 allele with human disease, and it is the strongest association between an HLA marker and a chemical-related occupational disease described thus far.
HLA-B Binding (association) of associated with occupational diseases and disease
1) Confidence 0.48 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2072824 Disease Relevance 1.03 Pain Relevance 0.03
These combined results demonstrate how the deeply embedded polymorphic heavy-chain residue 116 influences the flexibility of the peptide binding groove in a subtype-dependent manner, a feature that could also influence the recognition of the HLA-B27 complexes by effector cells.
HLA-B27 Binding (recognition) of in groove
2) Confidence 0.48 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18178223 Disease Relevance 0.14 Pain Relevance 0.06
The association of HLA-B27 with ankylosing spondylitis and other spondyloarthropathies ranks among the strongest between any HLA antigen and a human disease.
HLA-B27 Binding (association) of associated with spinal inflammation and disease
3) Confidence 0.48 Published 2002 Journal Tissue Antigens Section Abstract Doc Link 12445302 Disease Relevance 0.26 Pain Relevance 0.10
The association with HLA-B27 has been demonstrated worldwide, and evidence for a role of HLA-B27 in disease comes from linkage and association studies in humans, and transgenic animal models.
HLA-B27 Binding (association) of associated with targeted disruption and disease
4) Confidence 0.48 Published 2004 Journal Curr. Mol. Med. Section Abstract Doc Link 15011955 Disease Relevance 0.70 Pain Relevance 0.23
Thus although the association between ankylosing spondylitis and HLA-B27 has been known for 11 years we are not able to define a closer genetic marker for the disease or indeed to define the mechanism by which B27 is involved with the disease process.
HLA-B27 Binding (association) of associated with spinal inflammation and disease
5) Confidence 0.48 Published 1985 Journal Ciba Found. Symp. Section Abstract Doc Link 3851720 Disease Relevance 0.84 Pain Relevance 0.10
Ankylosing spondylitis in a patient with myelodysplastic syndrome: an association with HLA-B27 or coincidence?
HLA-B27 Binding (association) of associated with spinal inflammation and myelodysplastic syndromes
6) Confidence 0.48 Published 2009 Journal Rheumatol. Int. Section Title Doc Link 18841370 Disease Relevance 1.46 Pain Relevance 0.68
The relevance of these data is discussed in connection with the mapping of functional sites of HLA class I antigens and with the association between HLA-B27 and ankylosing spondylitis.
HLA-B27 Binding (association) of associated with spinal inflammation
7) Confidence 0.48 Published 1985 Journal Biochemistry Section Abstract Doc Link 2408663 Disease Relevance 0.16 Pain Relevance 0.16
The strong association of the human MHC class I allele HLA-B27 with the development of the chronic inflammatory disease ankylosing spondylitis (AS) is clear and has been known for over three decades.
MHC class I allele HLA-B27 Spec (clear) Binding (association) of associated with spinal inflammation, inflammation and disease
8) Confidence 0.48 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19731631 Disease Relevance 0.47 Pain Relevance 0.33
Apart from the associations with HLA-B7 and HLA-Cw*0702 (see below), there was one other apparently significant association, i.e. with HLA-Cw15, before correction for multiple testing.
HLA-B7 Binding (associations) of
9) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.10 Pain Relevance 0
Two of those early studies [16,17] reported an increased risk of AD associated with HLA-B7.
HLA-B7 Binding (associated) of associated with disease
10) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.85 Pain Relevance 0
Ankylosing spondylitis (AS) is universally associated with human leukocyte antigen B27 (HLA-B27), although other genes could determine the development and clinical expression of the disease.
HLA-B27 Binding (associated) of in leukocyte associated with spinal inflammation and disease
11) Confidence 0.48 Published 2004 Journal Hum. Immunol. Section Abstract Doc Link 14969772 Disease Relevance 0.49 Pain Relevance 0.39
The association of HLA-B27 with ankylosing spondylitis accounts for nearly 40% of the total disease risk.
HLA-B27 Binding (association) of associated with spinal inflammation and disease
12) Confidence 0.48 Published 2006 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 16777585 Disease Relevance 0.33 Pain Relevance 0.20
These results suggest that uveitis and ankylosing spondylitis are independent diseases occurring on their own and strongly associated with HLA-B 27.
HLA-B 27 Binding (associated) of associated with spinal inflammation, disease and uveitis
13) Confidence 0.48 Published 1979 Journal Ann Ophthalmol Section Abstract Doc Link 573580 Disease Relevance 0.81 Pain Relevance 0.26
Here, we report that HLA-B*2709 is not associated with AS, as it was not found in patients.
HLA-B Binding (associated) of associated with spinal inflammation
14) Confidence 0.47 Published 1995 Journal Eur. J. Immunol. Section Abstract Doc Link 7489765 Disease Relevance 0.69 Pain Relevance 0.33
Ankylosing spondylitis (AS) is an autoimmune disorder strongly associated with HLA-B27.
HLA-B27 Binding (associated) of associated with spinal inflammation and autoimmune disease
15) Confidence 0.47 Published 1995 Journal Eur. J. Immunol. Section Abstract Doc Link 7489765 Disease Relevance 0.65 Pain Relevance 0.33
Our results indicate that association of HLA-B27 subtypes with ankylosing spondylitis does not correlate with higher peptide sharing among disease-associated subtypes or with obvious peptide motifs.
HLA-B27 Binding (association) of associated with spinal inflammation and disease
16) Confidence 0.47 Published 2006 Journal Eur. J. Immunol. Section Abstract Doc Link 16783853 Disease Relevance 0.31 Pain Relevance 0.15
Structure and immune recognition of HLA-B27 antigens: implications for disease association.
HLA-B27 Binding (recognition) of associated with disease
17) Confidence 0.47 Published 1990 Journal Scand. J. Rheumatol. Suppl. Section Title Doc Link 1701918 Disease Relevance 0.19 Pain Relevance 0.10
HLA-B27 is strongly associated with susceptibility to ankylosing spondylitis and other spondyloarthropathies.
HLA-B27 Binding (associated) of associated with spinal inflammation
18) Confidence 0.47 Published 1990 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 1701918 Disease Relevance 0.17 Pain Relevance 0.10
HLA-B27 is strongly associated with ankylosing spondylitis.
HLA-B27 Binding (associated) of associated with spinal inflammation
19) Confidence 0.47 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11435436 Disease Relevance 0.19 Pain Relevance 0.10
Its binding to HLA-B27 subtypes in vivo correlated better than B27-(169-179) with association to spondyloarthropathy.
HLA-B27 Binding (binding) of
20) Confidence 0.47 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11435436 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox