INT187803

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.24
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
spinal 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 248 100.00 Very High Very High Very High
antinociception 10 98.76 Very High Very High Very High
Lasting pain 14 96.08 Very High Very High Very High
Pain 64 92.20 High High
Spinal cord 40 85.92 High High
ischemia 4 76.08 Quite High
Opioid 2 56.00 Quite High
cINOD 2 53.92 Quite High
Glutamate receptor 28 51.92 Quite High
antagonist 4 50.40 Quite High
Disease Link Frequency Relevance Heat
Pain 84 96.08 Very High Very High Very High
Brain Hemorrhage 4 76.08 Quite High
Nervous System Injury 8 60.64 Quite High
INFLAMMATION 2 53.52 Quite High
Hypersensitivity 10 46.96 Quite Low
Nociception 18 5.00 Very Low Very Low Very Low
Ganglion Cysts 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the first four mechanisms, glutamate transporter inhibitors lead to an increase in spinal extracellular glutamate levels, whereas, in the last one, glutamate transporter inhibitors block the reversed glutamate transporter-mediated glutamate release, and reduce extracellular glutamate levels (Fig. 4).
Negative_regulation (block) of Localization (release) of glutamate transporter-mediated in spinal associated with glutamate
1) Confidence 0.23 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.76 Pain Relevance 1.83
It is possible that blocking the reversed glutamate transporter-mediated glutamate release is an underlying mechanism of antinociception produced by glutamate transporter inhibition under chronic pain conditions.
Negative_regulation (blocking) of Localization (release) of glutamate transporter-mediated associated with antinociception, glutamate and lasting pain
2) Confidence 0.23 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.48 Pain Relevance 1.37

General Comments

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