INT187819

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2011
Negated 6
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 12.89
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
accessory cells 1
Th17 cells 1
T cell 1
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 384 100.00 Very High Very High Very High
tolerance 38 99.92 Very High Very High Very High
Inflammation 417 98.80 Very High Very High Very High
imagery 45 98.12 Very High Very High Very High
Arthritis 83 97.68 Very High Very High Very High
rheumatoid arthritis 73 91.00 High High
fibrosis 189 88.68 High High
Infliximab 36 73.28 Quite High
chemokine 32 68.56 Quite High
spinal inflammation 45 67.68 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 22 99.92 Very High Very High Very High
Infection 88 99.78 Very High Very High Very High
Fibrosis 163 99.16 Very High Very High Very High
Syndrome 243 99.10 Very High Very High Very High
INFLAMMATION 428 98.80 Very High Very High Very High
Targeted Disruption 73 98.76 Very High Very High Very High
Spontaneous Abortion 34 97.84 Very High Very High Very High
Arthritis 76 97.68 Very High Very High Very High
Fetal Resorption 2 96.64 Very High Very High Very High
Toxicity 23 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When CD4+ T cells were differentiated in the presence of mature BMDC, we observed a significant decrease in the percentage of Th17 cells and, as expected, an opposing effect on IFN-?
Regulation (effect) of IFN in Th17 cells
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
In order to confirm the inhibitory action of apigenin, its effect on the IFN-?
Regulation (effect) of IFN
2) Confidence 0.44 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
Here, there are several lines of evidences to explain this discrepancy in IFN-?
Regulation (discrepancy) of IFN
3) Confidence 0.44 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 1.03 Pain Relevance 0
Additionally changes in IFN-?
Regulation (changes) of IFN
4) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.79 Pain Relevance 0.11
Because of the pharmacology and kinetics of CIFN, its serum levels change daily; high levels after subcutaneous injection are followed by a day of low serum concentrations.
Regulation (change) of IFN
5) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727894 Disease Relevance 0.16 Pain Relevance 0
In murine models vaccinated with the same TRYP vaccine, a high ratio of pre-challenge IFN-?
Regulation (challenge) of IFN
6) Confidence 0.44 Published 2009 Journal Vaccine Section Body Doc Link PMC2663027 Disease Relevance 0.16 Pain Relevance 0
Correlations with changes in IFN-?
Regulation (changes) of IFN
7) Confidence 0.44 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.13 Pain Relevance 0.39
-gliadin protein was shown to down-regulate lymph node T cell proliferation and IFN-?
Regulation (regulate) of IFN in T cell
8) Confidence 0.44 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.18 Pain Relevance 0.04
At the end of the incubation period, supernatants were collected for IFN-?
Regulation (collected) of IFN
9) Confidence 0.44 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 0.43 Pain Relevance 0.03
After the activation of self-reactive lymphocyte clones and of bystander and accessory cells in the acute phase, IFN-?
Regulation (After) of IFN in accessory cells
10) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.42 Pain Relevance 0.62
in DS are likely to be related to the presence of several IFN receptor genes in chromosome 21 including IFNGR2, which is one of the subunits of the IFN-?
Regulation (several) of IFN associated with syndrome
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.04 Pain Relevance 0.05
In contrast, the study reported here has investigated the response of cells to LPS and IFN-?
Spec (investigated) Regulation (response) of IFN
12) Confidence 0.44 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1590031 Disease Relevance 0.30 Pain Relevance 0
These effects on IFN-?
Regulation (effects) of IFN
13) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.09 Pain Relevance 0.09
In addition, the specificity of juglone on IFN-?
Regulation (juglone) of IFN
14) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.28 Pain Relevance 0.07
Indeed, juglone did not affect IFN-?
Neg (not) Regulation (affect) of IFN
15) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.37 Pain Relevance 0.10
H. pylori infection also down-regulated the IFN-?
Regulation (regulated) of IFN associated with infection
16) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.52 Pain Relevance 0.03
were elevated during active disease (Table 2). 1-week after treatment, there was significant downregulation of IL-12 and IL-10 (P<0.005) in the responders compared to untreated condition, however, there was no significant change in the levels of IFN-?
Neg (no) Regulation (change) of IFN associated with disease
17) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.58 Pain Relevance 0.20
[41], or intracellular concentrations of IL-4, IL-6, IL-10 and IFN-?
Regulation (concentrations) of IFN
18) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911873 Disease Relevance 0.15 Pain Relevance 0.14
In conclusion, our study provides evidence that alterations in both the CD4+/CD8+ and IFN-?
Regulation (alterations) of IFN
19) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.49 Pain Relevance 0.19
The findings also suggest that the lack of C1q or C3 prevents induction of intranasal tolerance by modulating local IFN-?
Regulation (modulating) of IFN associated with tolerance
20) Confidence 0.26 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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