INT187828

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
blood 2
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 5 96.36 Very High Very High Very High
Inflammation 18 95.12 Very High Very High Very High
Pain 22 62.40 Quite High
Osteoarthritis 22 50.00 Quite Low
COX-2 inhibitor 1 10.88 Low Low
antagonist 2 5.88 Low Low
bradykinin 11 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 6 96.36 Very High Very High Very High
INFLAMMATION 18 95.12 Very High Very High Very High
Pre-eclampsia 33 85.60 High High
Pain 19 62.40 Quite High
Disease 16 53.00 Quite High
Osteoarthritis 22 50.00 Quite Low
Cardiovascular Disease 1 14.00 Low Low
Stroke 1 11.84 Low Low
Increased Venous Pressure Under Development 13 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The low levels of Ang-(1–7) and ACE2 in the RUPP model may represent an inhibition of the vasodilator arm of the renin-angiotensin system associated with factors generated by the reduced placental blood flow (sFlt-1, TNF-?
Spec (may) Negative_regulation (represent) of Gene_expression (levels) of ACE2 in blood
1) Confidence 0.29 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0
The protection of matrix degradation in response to IL-1 by sierrasil may reflect a reduction in matrix metalloprotease (MMP) production (also transcriptionally regulated in response to IL-1?)
Negative_regulation (reduction) of Gene_expression (production) of metalloprotease
2) Confidence 0.03 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.45 Pain Relevance 0.26

General Comments

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