INT18785

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.03
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nisch) plasma membrane (Nisch) cytoplasm (Nisch)
Anatomy Link Frequency
brain stem 2
endothelial cells 1
liver 1
Nisch (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 35 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
medulla 20 99.68 Very High Very High Very High
agonist 9 99.10 Very High Very High Very High
antidepressant 4 98.06 Very High Very High Very High
Rostral ventrolateral medulla 6 97.00 Very High Very High Very High
noradrenaline 3 92.96 High High
Catecholamine 1 83.32 Quite High
Opioid 3 83.04 Quite High
excitatory amino acid 1 78.64 Quite High
Disease Link Frequency Relevance Heat
Hypertension 4 98.52 Very High Very High Very High
Diabetes Mellitus 1 79.44 Quite High
Obesity 1 78.04 Quite High
Increased Venous Pressure Under Development 1 73.44 Quite High
Stroke 3 71.44 Quite High
Pressure Volume 2 Under Development 1 65.04 Quite High
Left Ventricular Hypertrophy 2 61.20 Quite High
Hypertrophy 1 51.04 Quite High
Bordatella Infection 2 46.88 Quite Low
Renal Insufficiency 3 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of [3H]idazoxan, a selective benzodioxan antagonist, to imidazoline receptor on intact fresh hepatocytes (Bmax = 801 +/- 23 fmol/mg protein, Kd = 11 +/- 0.8 nM) and to liver membranes (Bmax = 400 +/- 38 fmol/mg protein, Kd = 10 +/- 2 nM) was saturable at 4 degrees C within 3.5 h and at 30 degrees C within 30 min, respectively.
imidazoline receptor Binding (Binding) of in liver associated with antagonist
1) Confidence 0.43 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1981751 Disease Relevance 0 Pain Relevance 0.05
Herein, the prototypic antidepressant, imipramine (IMI), has been studied in regard to its treatment effects on [125I]p-iodoclonidine binding to both alpha 2 AR and IR1 in rat brainstem membranes.
IR1 Binding (binding) of in brainstem associated with medulla and antidepressant
2) Confidence 0.36 Published 1997 Journal Life Sci. Section Abstract Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.45
Norepinephrine, which has high affinity for the alpha 2 receptor and low affinity to the imidazoline receptor, partially antagonized NMDA-induced hypertension.
imidazoline receptor Binding (affinity) of associated with hypertension
3) Confidence 0.35 Published 1997 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 9310204 Disease Relevance 0.10 Pain Relevance 0.87
It is considered as ligand for imidazoline receptor due to the similarity of chemical structure.
imidazoline receptor Binding (ligand) of
4) Confidence 0.17 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19822195 Disease Relevance 0.08 Pain Relevance 0.29
These results suggest that agmatine can bind to a cell surface imidazoline receptor on endothelial cells and can stimulate nitric oxide production by increasing cytosolic calcium.
imidazoline receptor Binding (bind) of in endothelial cells
5) Confidence 0.15 Published 1997 Journal Proc. Assoc. Am. Physicians Section Abstract Doc Link 9010916 Disease Relevance 0.14 Pain Relevance 0.07
The alpha-2 adrenoceptor agonists clonidine, UK14, 304 and rilmenidine, which bind to the imidazoline preferring receptor, and guanabenz which does not, dose-dependently substituted for (i.e. > 80% total responding was clonidine associated) the clonidine-induced cue in doses up to 0.02, 0.16, 1.25 and 0.32 mg kg-1, respectively.
imidazoline preferring receptor Binding (bind) of associated with agonist and clonidine
6) Confidence 0.12 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870887 Disease Relevance 0 Pain Relevance 0.82
A review of the literature documenting ligand affinities for idazoxan-preferring (I2) imidazoline binding site subtypes and drug affinities for DAO enzymes indicates that some of the I2 sites described elsewhere may correspond to DAO and not to an imidazoline receptor.
imidazoline receptor Neg (not) Binding (correspond) of
7) Confidence 0.06 Published 1995 Journal Prog. Brain Res. Section Abstract Doc Link 8584654 Disease Relevance 0.08 Pain Relevance 0.15
Receptor binding studies demonstrate that moxonidine binds with an affinity for the imidazoline I1 receptor that is thirty-three times more effective than is alpha(2) receptor binding, while for clonidine the difference is only four times.
imidazoline I1 receptor Binding (binding) of associated with clonidine
8) Confidence 0.06 Published 1997 Journal J Hum Hypertens Section Abstract Doc Link 9321737 Disease Relevance 0.22 Pain Relevance 0.35
Moxonidine binds with an affinity for the imidazoline I1 receptor that is 33 times more effective than is alpha2-receptor binding.
imidazoline I1 receptor Binding (binds) of
9) Confidence 0.05 Published 1999 Journal J Hypertens Suppl Section Abstract Doc Link 10489098 Disease Relevance 0.21 Pain Relevance 0.34
Receptor binding studies demonstrate that moxonidine binds with an affinity for the imidazoline I1 receptor that is thirty-three times more effective than is alpha(2) receptor binding, while for clonidine the difference is only four times.
imidazoline I1 receptor Binding (binds) of associated with clonidine
10) Confidence 0.05 Published 1997 Journal J Hum Hypertens Section Abstract Doc Link 9321737 Disease Relevance 0.21 Pain Relevance 0.35
In the present report we have used [3H]idazoxan to characterize the rabbit renal imidazoline preferring site by defining its plasmalemma distribution, its regulation by cations and the type of interaction with the clonidine displacing substance (CDS), a putative endogenous ligand for the imidazoline receptor.
imidazoline receptor Binding (interaction) of associated with clonidine
11) Confidence 0.01 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2153803 Disease Relevance 0 Pain Relevance 0.17
Clonidine and cirazoline bind with high affinity to a nonadrenergic site in the brain stem, the so-called imidazoline I1 receptor.
imidazoline I1 receptor Binding (bind) of in brain stem associated with clonidine
12) Confidence 0.01 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7545885 Disease Relevance 0 Pain Relevance 0.36

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