INT18786

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Context Info
Confidence 0.19
First Reported 1990
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adra2a, Nisch) cytoplasm (Adra2a, Nisch) cytosol (Nisch)
signal transduction (Adra2a) signal transducer activity (Adra2a)
Anatomy Link Frequency
liver 1
Adra2a (Rattus norvegicus)
Nisch (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 19 100.00 Very High Very High Very High
agonist 7 100.00 Very High Very High Very High
antagonist 6 98.68 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alpha-2 adrenoceptor agonists clonidine, UK14, 304 and rilmenidine, which bind to the imidazoline preferring receptor, and guanabenz which does not, dose-dependently substituted for (i.e. > 80% total responding was clonidine associated) the clonidine-induced cue in doses up to 0.02, 0.16, 1.25 and 0.32 mg kg-1, respectively.
alpha-2 adrenoceptor Binding (bind) of imidazoline preferring receptor associated with agonist and clonidine
1) Confidence 0.19 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870887 Disease Relevance 0 Pain Relevance 0.83
This cue may be mediated by its alpha-2 adrenoceptor agonist properties and/or its affinity for the non-adrenoceptor imidazoline preferring receptor.
alpha-2 adrenoceptor Binding (affinity) of imidazoline preferring receptor associated with agonist
2) Confidence 0.16 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870887 Disease Relevance 0 Pain Relevance 0.68
All guanidine type alpha 2-adrenoceptor drugs (e.g. guanbenz, guanoxan) and imidazolines (e.g., UK-14,304, naphazoline) competed with high affinity for the liver imidazoline receptor.
guanidine type alpha 2-adrenoceptor Binding (affinity) of liver imidazoline receptor in liver
3) Confidence 0.14 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1981751 Disease Relevance 0 Pain Relevance 0.19

General Comments

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