INT187883

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.59
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mod2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 82.24 Quite High
Calcium channel 5 79.44 Quite High
tolerance 60 73.88 Quite High
metalloproteinase 3 63.20 Quite High
cytokine 57 34.96 Quite Low
Inflammation 42 34.32 Quite Low
vincristine 8 29.04 Quite Low
fibrosis 3 27.44 Quite Low
Bioavailability 24 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 158 100.00 Very High Very High Very High
Recurrence 12 99.48 Very High Very High Very High
Disease 78 97.24 Very High Very High Very High
Death 60 96.28 Very High Very High Very High
Apoptosis 149 95.84 Very High Very High Very High
Breast Cancer 21 95.12 Very High Very High Very High
Cancer 261 94.44 High High
Lymphatic System Cancer 157 91.52 High High
Pancreatic Cancer 4 77.92 Quite High
Toxicity 56 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They are also called MDR modulators and MDR reverters.
Gene_expression (modulators) of MDR
1) Confidence 0.18 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.06 Pain Relevance 0.04
The resistance mechanism is called typical MDR or classical MDR when overexpression of the membrane efflux pumps is involved in MDR.
Gene_expression (overexpression) of MDR
2) Confidence 0.16 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.40 Pain Relevance 0
The resistance mechanism is called typical MDR or classical MDR when overexpression of the membrane efflux pumps is involved in MDR.
Gene_expression (overexpression) of MDR
3) Confidence 0.16 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.34 Pain Relevance 0
The overall MDR was longer at 1.3 years.
Gene_expression (overall) of MDR
4) Confidence 0.11 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.58 Pain Relevance 0
The MDR for patients was 6.5 months for all 131I-TST responders.
Gene_expression (responders) of MDR
5) Confidence 0.11 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.52 Pain Relevance 0
M Dox to maintain its MDR properties [25].


Gene_expression (properties) of MDR
6) Confidence 0.11 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.12 Pain Relevance 0
Oxidative stress and MDR
Gene_expression (stress) of MDR associated with stress
7) Confidence 0.07 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.97 Pain Relevance 0.04
Role of redox-sensitive signaling proteins and MDR
Gene_expression (proteins) of MDR
8) Confidence 0.07 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.88 Pain Relevance 0.03
Overexpression of Pgp, MDR-associated-protein 1 (MRP1/ABCC1) or ABCG2 has been positively correlated with the evolution of MDR as well as cross-resistance to structurally unrelated anti-neoplastic drugs in a clinical tumor burden [96].
Gene_expression (Overexpression) of MDR associated with cancer
9) Confidence 0.06 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.73 Pain Relevance 0.04

General Comments

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