INT187888
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Although the exact site and number of Pgp binding with drugs have not yet been determined, the important binding sites such as TMD 4, 5, 6, 10, 11 and 12 have been determined [181] whereas substrate drugs do not bind to NBDs [182].
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On the other hand, the flavonoid, kaempferide, is bifunctional in that it would partially block the binding of the antiprogestin RU-486 in the cytoplasm domain of Pgp and block ATP binding [195] (Fig. 4). | |||||||||||||||
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Although the exact site and number of Pgp binding with drugs have not yet been determined, the important binding sites such as TMD 4, 5, 6, 10, 11 and 12 have been determined [181] whereas substrate drugs do not bind to NBDs [182].
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Pgp undergoes conformational changes upon binding of nucleotide to the NBDs [174]. | |||||||||||||||
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Methadone is in the intermediate range in this respect, with a ratio of 2.6 regarding its possible Pgp interaction (79). | |||||||||||||||
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The associated ratio of 1.2 for morphine indicates a minute risk of interaction with Pgp substrates; morphine is also a substrate for probenecid-sensitive transporters (83). | |||||||||||||||
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General Comments
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