INT187888

Context Info Confidence 0.32 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 0.40 Pain Relevance 1.35

phosphatase activity (Pgp) carbohydrate metabolic process (Pgp) molecular_function (Pgp) cellular_component (Pgp)

Pgp (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 38 99.48 methadone 2 98.20 Opioid 16 85.68 Oxycodone 22 79.80 Codeine 6 60.92 Glutamate 8 55.28 Neurotransmitter 4 53.80 positron emission tomography 8 33.04 Bioavailability 32 29.52 vincristine 4 21.00

Disease Link Frequency Relevance Heat Cancer 48 75.28 Primary Sclerosing Cholangitis 12 70.40 Drug Induced Neurotoxicity 4 65.44 Toxicity 16 62.20 Leukemia 4 20.20 Cv Unclassified Under Development 8 14.84 Disease 24 5.00 Breast Cancer 10 5.00 Adrenoleukodystrophy 4 5.00 Hypoxia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the exact site and number of Pgp binding with drugs have not yet been determined, the important binding sites such as TMD 4, 5, 6, 10, 11 and 12 have been determined [181] whereas substrate drugs do not bind to NBDs [182].

Pgp Binding (binding) of

1) Confidence 0.32 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.08 Pain Relevance 0

On the other hand, the flavonoid, kaempferide, is bifunctional in that it would partially block the binding of the antiprogestin RU-486 in the cytoplasm domain of Pgp and block ATP binding [195] (Fig. 4).

Pgp Binding (binding) of

2) Confidence 0.28 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.25 Pain Relevance 0

Although the exact site and number of Pgp binding with drugs have not yet been determined, the important binding sites such as TMD 4, 5, 6, 10, 11 and 12 have been determined [181] whereas substrate drugs do not bind to NBDs [182].

Pgp Binding (binding) of

3) Confidence 0.25 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.08 Pain Relevance 0

Pgp undergoes conformational changes upon binding of nucleotide to the NBDs [174].

Pgp Binding (binding) of

4) Confidence 0.24 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0 Pain Relevance 0.11

Methadone is in the intermediate range in this respect, with a ratio of 2.6 regarding its possible Pgp interaction (79).

Pgp Binding (interaction) of associated with methadone

5) Confidence 0.13 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.60

The associated ratio of 1.2 for morphine indicates a minute risk of interaction with Pgp substrates; morphine is also a substrate for probenecid-sensitive transporters (83).

Pgp Binding (interaction) of associated with morphine

6) Confidence 0.09 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.65

General Comments

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