INT187889

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp) carbohydrate metabolic process (Pgp) molecular_function (Pgp)
cellular_component (Pgp)
Pgp (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 3 99.98 Very High Very High Very High
Bioavailability 24 93.00 High High
Neurotransmitter 3 32.72 Quite Low
Glutamate 6 29.12 Quite Low
Opioid 3 27.52 Quite Low
vincristine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 36 85.40 High High
Toxicity 12 82.48 Quite High
Drug Induced Neurotoxicity 3 76.60 Quite High
Inflammatory Bowel Disease 3 72.36 Quite High
Disease 18 71.44 Quite High
Primary Sclerosing Cholangitis 9 53.84 Quite High
Hypoxia 3 16.04 Low Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Adrenoleukodystrophy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, some drugs could increase the expression of Pgp.
Positive_regulation (increase) of Gene_expression (expression) of Pgp
1) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.27 Pain Relevance 0.18
St John's Wort used as an antidepressant increases the expression of Pgp, so it could significantly lower the serum concentration of indinavir or cyclosporin [166].
Positive_regulation (increases) of Gene_expression (expression) of Pgp associated with antidepressant
2) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.26 Pain Relevance 0.18
Overexpression of ABC transporters such as Pgp, MRP and BCRP has been shown to be responsible for the major portion of MDR.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Pgp
3) Confidence 0.35 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.31 Pain Relevance 0

General Comments

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