INT187894

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.97
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 64.64 Quite High
Inflammation 4 45.84 Quite Low
Bioavailability 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
methadone 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 16 99.96 Very High Very High Very High
Cancer 18 99.68 Very High Very High Very High
Exanthema 8 90.80 High High
Infection 34 90.08 High High
Breast Cancer 2 81.00 Quite High
Hypoglycemia 1 74.36 Quite High
Ataxia 1 72.36 Quite High
Sideroblastic Anemia 1 72.04 Quite High
Intrahepatic Cholestasis 1 70.80 Quite High
Disease 19 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the potential severity of ABC hypersensitivity calls for prudence.
Positive_regulation (severity) of Gene_expression (severity) of ABC associated with hypersensitivity
1) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.57 Pain Relevance 0
Functions of ABC transporters
Positive_regulation (transporters) of Gene_expression (transporters) of ABC
2) Confidence 0.06 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.93 Pain Relevance 0.03
The overexpression of ABC transporters is another mechanism for acquisition of miltefosine resistance, through reduction of the drug intracellular accumulation [48, 52].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ABC
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0 Pain Relevance 0
Overexpression of the membrane-bound ATP-binding cassette (ABC) transporters on the surfaces of leishmanias is another mechanism of antimonial resistance.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ABC
4) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.20 Pain Relevance 0
Overexpression of ABC transporters concerns laboratory-derived and in-field resistant parasites [31, 34].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ABC
5) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.28 Pain Relevance 0

General Comments

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