INT18793

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 1990
Negated 0
Speculated 3
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 3.20

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extracellular region (Crh, Penk) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Crh (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 40 100.00 Very High Very High Very High
Dynorphin 35 100.00 Very High Very High Very High
Dopamine 5 99.48 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effects of corticotropin-releasing factor (CRF) on the in vitro release of methionine-enkephalin (Met-enkephalin) and dynorphin in neostriatal slices taken from rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the nigrostriatal DA pathway.
corticotropin-releasing factor Spec (examined) Regulation (effects) of Localization (release) of methionine-enkephalin associated with dynorphin and enkephalin
1) Confidence 0.59 Published 1990 Journal Brain Res. Section Abstract Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.56
However, the results of this study demonstrate that the action of CRF on Met-enkephalin as well as dynorphin release from the rat neostriatum is DA dependent.
CRF Regulation (dependent) of Localization (release) of Met-enkephalin associated with dynorphin and enkephalin
2) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.78
This study examined the effects of corticotropin-releasing factor (CRF) on the in vitro release of methionine-enkephalin (Met-enkephalin) and dynorphin in neostriatal slices taken from rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the nigrostriatal DA pathway.
corticotropin-releasing factor Spec (examined) Regulation (effects) of Localization (release) of Met-enkephalin associated with dynorphin and enkephalin
3) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.56
Nigrostriatal dopamine mediates the stimulatory effects of corticotropin releasing factor on methionine-enkephalin and dynorphin release from the rat neostriatum.
corticotropin releasing factor Regulation (effects) of Localization (release) of methionine-enkephalin associated with dopamine, dynorphin and enkephalin
4) Confidence 0.49 Published 1990 Journal Brain Res. Section Title Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.75
This study examined the effects of corticotropin-releasing factor (CRF) on the in vitro release of methionine-enkephalin (Met-enkephalin) and dynorphin in neostriatal slices taken from rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the nigrostriatal DA pathway.
CRF Spec (examined) Regulation (effects) of Localization (release) of methionine-enkephalin associated with dynorphin and enkephalin
5) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.56

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