INT187994

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 12.97
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plaque 1
Carotid artery 1
CIMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 5 99.76 Very High Very High Very High
rheumatoid arthritis 457 99.60 Very High Very High Very High
Inflammation 182 98.46 Very High Very High Very High
Biofeedback 18 41.68 Quite Low
ischemia 4 41.44 Quite Low
Angina 63 30.20 Quite Low
cva 15 11.68 Low Low
imagery 12 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 97 100.00 Very High Very High Very High
Hypertension 41 100.00 Very High Very High Very High
INFLAMMATION 190 99.76 Very High Very High Very High
Rheumatoid Arthritis 462 99.60 Very High Very High Very High
Coronary Artery Disease 237 99.56 Very High Very High Very High
Stroke 97 99.12 Very High Very High Very High
Disease 184 98.44 Very High Very High Very High
Atherosclerosis 438 98.32 Very High Very High Very High
Metabolic Syndrome 64 98.08 Very High Very High Very High
Rupture 20 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While our study was too small to effectively model factors associated with cIMT in early RA, age and baseline CRP emerged from our analysis as the key determinants of cIMT in early RA, which deserve further testing in future studies.
cIMT Binding (associated) of associated with rheumatoid arthritis
1) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.11 Pain Relevance 0.30
The consistent association of cIMT with inflammatory markers supports the evidence that CV mortality in RA patients is associated with inflammation.
cIMT Binding (association) of associated with inflammation, inflammatory marker and rheumatoid arthritis
2) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.81 Pain Relevance 0.64
Age and the cIMT were closely associated in both our patient and matched healthy control populations.
cIMT Binding (associated) of
3) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.19 Pain Relevance 0.36
The role of inflammatory activity became clearer upon multivariate analysis, which revealed a strong association between the cIMT, age and CRP level at presentation (Table 3, adjusted R2 = 0.64).


cIMT Binding (association) of associated with inflammation
4) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.43 Pain Relevance 0.52
The association of the cIMT with age, continuous CV variables and disease activity variables was evaluated using linear regression analysis.
cIMT Binding (association) of associated with disease
5) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 0.47 Pain Relevance 0.15
The second step of the instrumental variables analysis, consistent with the confounder adjusted standard regression analysis, suggested no association between CRP and CIMT, though this was estimated with wide confidence intervals (table 5).
CIMT Neg (no) Binding (association) of
6) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.38 Pain Relevance 0
This null finding is assumed to represent a non-confounded and unbiased estimate of the association between CRP and CIMT because the existence of early stages of atherosclerosis cannot alter inherited haplotypes [15], and the potential confounders of the CRP-atherosclerosis association (e.g., obesity, smoking, physical inactivity or socioeconomic adversity) were distributed evenly among the different CRP haplotypes.
CIMT Binding (association) of associated with nicotine addiction, atherosclerosis and metabolic syndrome
7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.48 Pain Relevance 0
The association between serum CRP and CIMT attenuated towards the null in adjustments for obesity and other risk factors and this is consistent with several previous studies [7]–[9], [47].
CIMT Binding (association) of associated with metabolic syndrome
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.57 Pain Relevance 0.04
Furthermore, the null finding of CRP haplotype and CIMT is replicable as consistent findings have been obtained from this UK study and studies in a US and Finnish population [22], [24].
CIMT Spec (finding) Binding (finding) of
9) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0 Pain Relevance 0
The 4 major haplotypes from the SNPs were consistently associated with CRP level, but not with other risk factors that might confound the association between CRP and CIMT.
CIMT Spec (might) Binding (association) of
10) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.38 Pain Relevance 0.03
Lange et al. [24] suggest that CRP may affect plaque rupture rather than atherosclerosis in a study reporting an association of CRP genotype with incident CHD in a subgroup but no association with CIMT in the same subgroup or in the study population as a whole.
CIMT Neg (no) Binding (association) of in plaque associated with coronary artery disease, atherosclerosis and rupture
11) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 1.00 Pain Relevance 0
When examined using genetic variants as the instrument for serum CRP, there was no inferred association between CRP and CIMT.


CIMT Neg (no) Binding (association) of
12) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.26 Pain Relevance 0
For these reasons, it seems unlikely that population stratification would have masked a causal association between CRP and CIMT.
CIMT Binding (association) of
13) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0 Pain Relevance 0
In contrast, all of the risk factors were associated with serum CRP and/or CIMT (table 3).
CIMT Binding (associated) of
14) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.33 Pain Relevance 0
The total reduction of the magnitude of the CRP-CIMT association between the two models at the mean age of 61.0 was 75%.
CIMT Binding (association) of
15) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.44 Pain Relevance 0
However, as tHcy is positively associated with CIMT and negatively with FMD, any baseline differences in these measurements between the groups should have increased rather than reduced the probability of finding improved FMD and CIMT in the vitamin group at follow-up.
CIMT Binding (associated) of
16) Confidence 0.24 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.17 Pain Relevance 0
It was associated with cardiovascular risk factors, including hypertension, diabetes, and increased CIMT and independent predictors of multi-vessel disease in patients with coronary atherosclerosis.
CIMT Binding (associated) of associated with coronary artery disease, diabetes mellitus, hypertension and disease
17) Confidence 0.20 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771847 Disease Relevance 1.09 Pain Relevance 0
Carotid artery intima-media thickness (CIMT) has recently been recommended as a non-invasive tool for primary prevention of cardiovascular events; the association between CIMT and adverse cardiovascular events is well-known.
CIMT Binding (association) of in Carotid artery
18) Confidence 0.19 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2771847 Disease Relevance 0.27 Pain Relevance 0
0.31, P < 0.001), and there was no significant association between LDL-C and CIMT in the group treated with NA (R = ?
CIMT Binding (group) of
19) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.33 Pain Relevance 0
In a subsequent publication, the authors of the ARBITER 6-HALTS trial showed that increased exposure to ezetimibe was associated with CIMT progression.88
CIMT Binding (associated) of
20) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.37 Pain Relevance 0

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