INT188001

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 5.60
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (H2afx) chromosome (H2afx) nucleus (H2afx)
enzyme binding (H2afx) cell cycle (H2afx) DNA binding (H2afx)
Anatomy Link Frequency
poly 1
fibroblasts 1
H2afx (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 11 74.28 Quite High
Pain 6 48.16 Quite Low
Nicotine 1 37.20 Quite Low
cerebral cortex 42 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 99.08 Very High Very High Very High
Death 69 98.22 Very High Very High Very High
Ataxia 14 97.28 Very High Very High Very High
Disease 366 96.88 Very High Very High Very High
Targeted Disruption 353 94.60 High High
Chromosomal Instability 5 87.40 High High
Genomic Instability 2 86.28 High High
Genetic Translocation 5 85.96 High High
Adenovirus Infection 14 84.48 Quite High
Toxicity 15 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several proteins, such as the tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated H2AX (?
Phosphorylation (phosphorylated) of H2AX associated with cancer
1) Confidence 0.80 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.15 Pain Relevance 0.04
In consequence the histone H2Ax is phosphorylated and p53 accumulates in the cell.56 The degree of SM-induced DNA damage is decisive for the further cell fate.
Phosphorylation (phosphorylated) of H2Ax
2) Confidence 0.80 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.50 Pain Relevance 0
A very early step in the response of mammalian cells to DNA DSBs is the phosphorylation of histone H2AX at serine-139 at the sites of DNA damage.
Phosphorylation (phosphorylation) of H2AX
3) Confidence 0.70 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0 Pain Relevance 0
To investigate whether chrysotile induces phosphorylation of H2AX in MEF cells, we exposed cultures to either a 1- or 2-?
Phosphorylation (phosphorylation) of H2AX
4) Confidence 0.70 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0 Pain Relevance 0
The expression of phosphorylated H2AX as a function of DNA damage was then analyzed using flow cytometry.
Phosphorylation (phosphorylated) of H2AX
5) Confidence 0.70 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0 Pain Relevance 0
A very early step in the response of mammalian cells to DNA DSBs is the phosphorylation of histone H2AX at serine 139 at the sites of DNA damage (Lowndes and Toh 2005).
Phosphorylation (phosphorylation) of H2AX
6) Confidence 0.54 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.39 Pain Relevance 0
The accumulation of phosphorylated histone H2AX (?
Phosphorylation (phosphorylated) of H2AX
7) Confidence 0.54 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797839 Disease Relevance 0.21 Pain Relevance 0
Involvement of OGG1 indicates existence of base damages, whereas our results of H2AX phosphorylation (?
Phosphorylation (phosphorylation) of H2AX
8) Confidence 0.47 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.97 Pain Relevance 0
Because DNA–PK was reported to phosphorylate H2AX (Stiff et al., 2004), one might ask whether the reduced DNA–PK activity (Fig. 5) could be contradictory to H2AX phosphorylation.
Phosphorylation (phosphorylation) of H2AX
9) Confidence 0.47 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.56 Pain Relevance 0
Because DNA–PK was reported to phosphorylate H2AX (Stiff et al., 2004), one might ask whether the reduced DNA–PK activity (Fig. 5) could be contradictory to H2AX phosphorylation.
Phosphorylation (phosphorylate) of H2AX
10) Confidence 0.47 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.53 Pain Relevance 0
However, other kinases, such as ataxia telangiectasia mutated (ATM), a mediator of DNA damage–induced cell death signaling (Lombard et al., 2005; for review see Sancar et al., 2004), are also known to phosphorylate H2AX (Fernandez-Capetillo et al., 2004; Lu et al., 2006), and activation of ATM has been observed in the HD pathology (Qi et al., 2007).
Phosphorylation (phosphorylate) of H2AX associated with ataxia, disease and death
11) Confidence 0.47 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.63 Pain Relevance 0
Remarkably the sole fact of the incubation with ANI was able to elicits H2AX phosphorylation in wild type but not in ATM deficient cells.
Phosphorylation (phosphorylation) of H2AX
12) Confidence 0.42 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.06 Pain Relevance 0
The data presented in this study strongly support a role for PARP-1 and poly (ADP-ribose) in ATM activation: in the absence of PARP-1 there is a deficient ATM-kinase activation in response to ionizing radiation as measured by intrinsic kinase activity and H2AX phosphorylation.
Phosphorylation (phosphorylation) of H2AX in poly
13) Confidence 0.42 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.21 Pain Relevance 0
As expected, reduction of Ku70 enhanced phosphorylation of H2AX (Fig. 7 D).
Phosphorylation (phosphorylation) of H2AX
14) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.17 Pain Relevance 0
Another study implicating polyQ-induced DNA damage showed phosphorylation of H2AX in PC12 cells expressing expanded polyQ proteins as well as in fibroblasts from HD and SCA2 patients (Giuliano et al., 2003).
Phosphorylation (phosphorylation) of H2AX in fibroblasts associated with disease
15) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.75 Pain Relevance 0
As a specific marker for DSBs, the levels of phosphorylated H2AX (?
Phosphorylation (phosphorylated) of H2AX
16) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox