INT188016

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 5.54
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TP53BP1) chromosome (TP53BP1) nucleus (TP53BP1)
intracellular (TP53BP1) cytoplasm (TP53BP1)
Anatomy Link Frequency
neurons 3
TP53BP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 48 94.16 High High
addiction 55 87.40 High High
Pyramidal cell 6 82.88 Quite High
imagery 18 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 70 99.84 Very High Very High Very High
Disease 672 99.12 Very High Very High Very High
Death 30 95.64 Very High Very High Very High
Telangiectasia 6 93.92 High High
Ataxia 18 93.32 High High
Stress 97 91.44 High High
Disease Progression 6 89.40 High High
Cancer 26 87.76 High High
Polyploidy 30 84.64 Quite High
Hypersensitivity 63 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of 53BP1/?
Gene_expression (analysis) of 53BP1
1) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.27 Pain Relevance 0.08
Because no 53BP1/?
Gene_expression (/) of 53BP1
2) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.08 Pain Relevance 0.03
It is thus possible that the observed effects of MW and heat shock at the level of 53BP1/?
Gene_expression (level) of 53BP1 associated with shock
3) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.77 Pain Relevance 0
We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/?
Gene_expression (/) of 53BP1
4) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1280397 Disease Relevance 0.35 Pain Relevance 0.04
This comparison showed that MWs affected both 53BP1 and ?
Gene_expression (affected) of 53BP1
5) Confidence 0.56 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.08 Pain Relevance 0
Further, the level of 53BP1 expression correlated well with AD diagnosis (p = 0.01, Table 2).
Gene_expression (expression) of 53BP1 associated with disease
6) Confidence 0.53 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.84 Pain Relevance 0
Case HCB07 had significant numbers of 53BP1-positive CDN neurons as well as several PCNA positive cells, likely indications of DNA damage.
Gene_expression (numbers) of 53BP1 in neurons
7) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.71 Pain Relevance 0.04
Case HCB07 had significant numbers of 53BP1-positive CDN neurons as well as several PCNA positive cells, likely indications of DNA damage.
Gene_expression (neurons) of 53BP1 in neurons
8) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.75 Pain Relevance 0.04
To determine whether the 53BP1 response was reflective of a broader ATM-dependent response to DNA damage, we examined ATM auto-phosphorylation with a phospho-ser1981 specific antibody (Figure 2C, D).
Spec (whether) Gene_expression (response) of 53BP1
9) Confidence 0.40 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.75 Pain Relevance 0
The cell cycle marker cyclin A (Figure 3 red arrow) and the DNA damage marker 53BP1 (Figure 3 black arrow) and P-ATM (Figure 3 blue arrow) were consistently found in different CDN neurons.
Gene_expression (found) of 53BP1 in neurons
10) Confidence 0.40 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.24 Pain Relevance 0.09
However, this case stained negative for DNA damage response markers 53BP1 and P-ATM.
Neg (negative) Gene_expression (negative) of 53BP1
11) Confidence 0.18 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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