INT188018

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 0.94
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (H2AFX) histone binding (H2AFX) chromosome (H2AFX)
nucleus (H2AFX) enzyme binding (H2AFX) cell cycle (H2AFX)
H2AFX (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 11 98.62 Very High Very High Very High
tolerance 36 88.64 High High
IPN 9 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
GABA receptor 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 10 99.08 Very High Very High Very High
Stress 32 96.92 Very High Very High Very High
Hypersensitivity 18 89.20 High High
Amebiasis 18 84.96 Quite High
Apoptosis 16 82.08 Quite High
Shock 14 78.64 Quite High
Dna Repair-deficiency Disorders 3 77.60 Quite High
Freckles 3 75.04 Quite High
Targeted Disruption 9 73.60 Quite High
Sprains And Strains 63 5.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (?
Phosphorylation (phosphorylated) of histone H2AX associated with stress, addiction and cancer
1) Confidence 0.64 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1280397 Disease Relevance 0.36 Pain Relevance 0.05
Like Chk2 phosphorylation, H2AX phosphorylation was induced by compound 15, but not by compound 13 (Figure 6D).
Phosphorylation (phosphorylation) of H2AX
2) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.15 Pain Relevance 0.04
Antibodies against phosphorylated H2AX (Ser139; clone JBW301) were from Millipore.


Phosphorylation (phosphorylated) of H2AX
3) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0 Pain Relevance 0
Early phosphorylation of E. histolytica H2AX histones after UV-C irradiation was consistent with DNA DSBs formation, suggesting chromatin remodeling and recruitment of histone-phosphorylating enzymes, as observed in other eukaryotic systems [22].
Phosphorylation (phosphorylation) of H2AX
4) Confidence 0.18 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Particularly, Saccharomyces cerevisiae H2A and Homo sapiens H2AX histones are rapidly phosphorylated in the chromatin micro-environment surrounding DNA DSBs, inducing nucleosome remodeling to promote accumulation of checkpoint and DNA repair proteins at these sites [8].
Phosphorylation (phosphorylated) of H2AX
5) Confidence 0.18 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.21 Pain Relevance 0
We further tested these cells for phosphorylation of histone H2AX, a chromatin modification that occurs near double strand DNA breaks (reviewed in [57],[58]).
Phosphorylation (phosphorylation) of histone H2AX
6) Confidence 0.18 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.13 Pain Relevance 0.04
Early EhH2AX histone phosphorylation correlates with the presence of DNA DSBs
Phosphorylation (phosphorylation) of EhH2AX
7) Confidence 0.16 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
However, these assays did not allow us to distinguish whether one or both EhH2AX proteins were phosphorylated.
Phosphorylation (phosphorylated) of EhH2AX
8) Confidence 0.16 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA DSBs induce early phosphorylation of yeast H2A (major H2A closer to mammalian H2AX) and human H2AX histones on a conserved serine residue located in the SQ motif at C terminus, producing ?
Phosphorylation (phosphorylation) of H2AX
9) Confidence 0.14 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
DNA double strand-breaks were evidenced in irradiated cells by TUNEL and comet assays and evaluation of the EhH2AX histone phosphorylation status.
Phosphorylation (phosphorylation) of EhH2AX
10) Confidence 0.12 Published 2008 Journal BMC Mol Biol Section Abstract Doc Link PMC2324109 Disease Relevance 0.08 Pain Relevance 0
Detection of phosphorylated EhH2AX histones
Phosphorylation (phosphorylated) of EhH2AX
11) Confidence 0.12 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
When a DSB is introduced in E. histolytica genome, EhH2AX histones become phosphorylated, which could induce chromatin remodeling and accumulation of the EhRAD52 epistasis group proteins at the DNA DSB site.
Phosphorylation (phosphorylated) of EhH2AX
12) Confidence 0.12 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
The presence of phosphorylated forms of EhH2AX histone (?
Phosphorylation (phosphorylated) of EhH2AX
13) Confidence 0.12 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox