INT188019

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.42
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TP53BP1) chromosome (TP53BP1) nucleus (TP53BP1)
intracellular (TP53BP1) cytoplasm (TP53BP1)
TP53BP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 66 99.52 Very High Very High Very High
headache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 99.98 Very High Very High Very High
Shock 84 98.64 Very High Very High Very High
Stress 66 97.82 Very High Very High Very High
Hypersensitivity 54 91.00 High High
Acoustic Neuroma 6 22.68 Low Low
Brain Tumor 6 21.84 Low Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Fatigue 6 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we show that even shorter exposure, 1 hr, produces a significant reduction in the 53BP1 level.
Negative_regulation (reduction) of 53BP1
1) Confidence 0.48 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.24 Pain Relevance 0.03
We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (?
Spec (analyzed) Negative_regulation (suppressor) of 53BP1 associated with stress, addiction and cancer
2) Confidence 0.40 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1280397 Disease Relevance 0.36 Pain Relevance 0.05
Several proteins, such as the tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated H2AX (?
Negative_regulation (suppressor) of 53BP1 associated with cancer
3) Confidence 0.40 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.16 Pain Relevance 0.04
Statistical analysis of these pooled data showed that 915 MHz exposure significantly reduced the number of 53BP1 and ?
Negative_regulation (reduced) of 53BP1
4) Confidence 0.36 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.16 Pain Relevance 0
Therefore, in the present study we confirm our previous finding that exposure at 915 MHz reduces 53BP1 foci in a manner similar to heat shock, suggesting that this frequency affects cells in a manner similar to a stress factor (Belyaev et al. 2002, 2005).
Negative_regulation (reduces) of 53BP1 associated with stress and shock
5) Confidence 0.35 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.32 Pain Relevance 0.07
Despite the fact that no heating was induced by MW exposure, the reduction in the number of 53BP1 and ?
Negative_regulation (reduction) of 53BP1
6) Confidence 0.35 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.18 Pain Relevance 0

General Comments

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