INT188021

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TP53BP1) chromosome (TP53BP1) nucleus (TP53BP1)
intracellular (TP53BP1) cytoplasm (TP53BP1)
Anatomy Link Frequency
lymphocytes 1
TP53BP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 8 93.60 High High
addiction 22 86.32 High High
Central nervous system 1 76.80 Quite High
imagery 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 28 99.98 Very High Very High Very High
Disease 112 99.84 Very High Very High Very High
Stress 29 94.36 High High
Neurodegenerative Disease 3 86.60 High High
Hypersensitivity 21 78.00 Quite High
Gliosis 2 76.72 Quite High
Medulloblastoma 1 72.12 Quite High
Cancer 9 69.92 Quite High
Dementia 4 37.20 Quite Low
Congenital Anomalies 3 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we found that MWs similar to heat shock induced significant reduction in the background level of 53BP1 foci (Belyaev et al. 2005).
Positive_regulation (induced) of 53BP1 associated with shock
1) Confidence 0.48 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.31 Pain Relevance 0.09
In an analysis of the 53BP1 foci in human lymphocytes after exposure to MWs from mobile telephones using the Global System for Mobile Communication (GSM) standard at 915 MHz, we did not find induction of 53BP1 foci (Belyaev et al. 2005).
Positive_regulation (induction) of 53BP1 in lymphocytes
2) Confidence 0.41 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280397 Disease Relevance 0.29 Pain Relevance 0.07
In the current report we show that the chromosome binding protein, 53BP1, and the activated DNA damage response kinase, P-ATM, are both significantly elevated in AD cases with Braak stage of V or above.
Positive_regulation (elevated) of 53BP1 associated with disease
3) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

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