INT188047

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 31.41
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
colon 2
bone marrow 2
neurons 2
macrophages 1
cardiomyocytes 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 26 99.40 Very High Very High Very High
antidepressant 8 99.32 Very High Very High Very High
cocaine 105 98.20 Very High Very High Very High
cINOD 78 93.76 High High
Nucleus accumbens 35 91.92 High High
Inflammation 213 90.40 High High
Potency 24 88.68 High High
Hippocampus 134 80.40 Quite High
fibrosis 122 80.28 Quite High
antagonist 51 79.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 905 100.00 Very High Very High Very High
Death 176 99.82 Very High Very High Very High
Disease 1105 99.76 Very High Very High Very High
Myocardial Infarction 879 99.72 Very High Very High Very High
Cancer 1157 99.44 Very High Very High Very High
Colon Cancer 269 99.44 Very High Very High Very High
Low Back Pain 28 99.40 Very High Very High Very High
Nasopharynx Cancer 145 99.20 Very High Very High Very High
Wound Healing 38 98.44 Very High Very High Very High
Injury 153 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the Wnt Signaling Pathway Prevents A?
Positive_regulation (activation) of Wnt
1) Confidence 0.58 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.77 Pain Relevance 0
Compounds such as IBU-PO, which mimic the activation of the Wnt signaling pathway, could eventually rescue neurons from cytotoxicity through GSK-3?
Positive_regulation (activation) of Wnt in neurons
2) Confidence 0.58 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.64 Pain Relevance 0.31
The activation of the canonical Wnt signaling pathway protects hippocampal neurons against the toxicity of Alzheimer's A?
Positive_regulation (activation) of Wnt in neurons associated with toxicity
3) Confidence 0.58 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.17 Pain Relevance 0
4 causes the inhibition of the canonical Wnt signaling pathway in PC12 cells upon stimulation with Wnt-7a as determined by luciferase activities and nuclear ?
Positive_regulation (causes) of Wnt
4) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.07 Pain Relevance 0
In vitro studies have shown that the activation of the canonical Wnt signaling pathway by Wnt-3a and Wnt-7a conditioned media were able to overcome the neurotoxic consequences induced by A?
Positive_regulation (activation) of Wnt
5) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.68 Pain Relevance 0.14
4 causes the inhibition of the canonical Wnt signaling pathway in PC12 cells upon stimulation with Wnt-7a as determined by luciferase activities and nuclear ?
Positive_regulation (stimulation) of Wnt
6) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.05 Pain Relevance 0
In vitro studies have shown that the activation of the canonical Wnt signaling pathway by Wnt-3a and Wnt-7a conditioned media were able to overcome the neurotoxic consequences induced by A?
Positive_regulation (activation) of Wnt
7) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.68 Pain Relevance 0.13
The protection observed is the result of the Wnt signaling activation, since the increase in the activity of GSK-3?
Positive_regulation (result) of Wnt
8) Confidence 0.42 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.73 Pain Relevance 0.45
In this context, we ask whether or not the activation of the Wnt signaling by anti-oxidant treatment increases the mRNA levels of some of the components of the Wnt pathway.
Spec (whether) Positive_regulation (activation) of Wnt
9) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.34 Pain Relevance 0
Results indicated that both Wnt-7a and Wnt-5a ligands were induced by the anti-oxidant treatment [52].
Positive_regulation (induced) of Wnt
10) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.34 Pain Relevance 0
As a result, we have studied whether or not the activation of the Wnt signaling pathway may be used as a therapeutic strategy to treat AD.
Positive_regulation (activation) of Wnt associated with disease
11) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.74 Pain Relevance 0
Results indicated that both Wnt-7a and Wnt-5a ligands were induced by the anti-oxidant treatment [52].
Positive_regulation (induced) of Wnt
12) Confidence 0.39 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.35 Pain Relevance 0
Lastly, a DNA damage protein (Gadd45a) and a MAP kinase (Mapk14), two other proteins recently associated with Wnt activation, were also differentially expressed in PB- and PTU-treated animals but not in NaI-treated animals (Hildesheim et al. 2004).
Positive_regulation (activation) of Wnt
13) Confidence 0.38 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.39 Pain Relevance 0
Recently we found that Fz1 mediates the activation of the canonical Wnt/?
Positive_regulation (activation) of Wnt
14) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.24 Pain Relevance 0
Rapid bony union in AS patients might be due to the activation of the Wnt pathway and BMP, which promote bone remodeling through bone formation and bone induction.
Positive_regulation (activation) of Wnt associated with spinal inflammation
15) Confidence 0.34 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2981776 Disease Relevance 0.58 Pain Relevance 0.27
Wnt activation inhibits the phosphorylation of ?
Positive_regulation (activation) of Wnt
16) Confidence 0.26 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.86 Pain Relevance 0
It was demonstrated that cardiogenin treatment of MSCs in vitro induced activation of several signaling pathways, including Wnt, TGF-?
Positive_regulation (induced) of Wnt
17) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637970 Disease Relevance 0.08 Pain Relevance 0
The Wnt family of glycoproteins are involved in activation of the Wnt /  ?
Positive_regulation (activation) of Wnt
18) Confidence 0.15 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.48 Pain Relevance 0
Fut8, a fucosyltransferase protein, also increased at 10-days of abstinence in this study, has been shown to increase upon Wnt/beta-catenin activation [76], indicating that there may be a coordinated activation of Wnt signaling during periods of abstinence from cocaine.
Positive_regulation (activation) of Wnt associated with cocaine
19) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.15 Pain Relevance 0.54
The authors attributed these effects to a lithium dependent wnt signalling induction by a down-regulation of GSK3?
Positive_regulation (induction) of wnt
20) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.39 Pain Relevance 0.18

General Comments

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