INT188074

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.11
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (GADD45A) response to stress (GADD45A)
Anatomy Link Frequency
finger 1
lung 1
T cells 1
GADD45A (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 4 96.48 Very High Very High Very High
cytokine 80 86.80 High High
Inflammation 78 74.24 Quite High
Nicotine 5 73.08 Quite High
COX2 1 71.16 Quite High
agonist 47 50.00 Quite Low
antagonist 6 18.44 Low Low
alcohol 10 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 99.10 Very High Very High Very High
Non-small-cell Lung Cancer 41 98.32 Very High Very High Very High
Apoptosis 243 98.16 Very High Very High Very High
Aging 64 97.48 Very High Very High Very High
Lung Cancer 62 95.32 Very High Very High Very High
Sprains And Strains 58 92.16 High High
Adenocarcinoma 6 90.92 High High
Bladder Cancer 2 89.08 High High
Shock 10 88.96 High High
Cancer 116 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lastly, a DNA damage protein (Gadd45a) and a MAP kinase (Mapk14), two other proteins recently associated with Wnt activation, were also differentially expressed in PB- and PTU-treated animals but not in NaI-treated animals (Hildesheim et al. 2004).
Gene_expression (expressed) of Gadd45a
1) Confidence 0.65 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.40 Pain Relevance 0
In addition, GADD45A expression may be regulated by AP-1 complexes containing JunD [66].
Gene_expression (expression) of GADD45A
2) Confidence 0.47 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.23 Pain Relevance 0
Strenuous physical load significantly increased HSP70, HSP32, Mn-SOD, Cu-Zn SOD, iNOS, GADD45, bcl-2, forkhead box O (FOXO3A) and SIRT1 expression after the marathon, while decreasing bax, SIRT3 and SIRT4 expression (P < 0.0001).


Gene_expression (expression) of GADD45
3) Confidence 0.46 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.39 Pain Relevance 0
In addition, Northern blot analysis showed that RNA levels of the SIRT1-dependent transcription factor FOXO3A and its target GADD45 were increased in the studied group after marathon (Figure 7).
Gene_expression (levels) of GADD45
4) Confidence 0.46 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.12 Pain Relevance 0
Sustained activation of p38 MAPK can be observed by simultaneous stimulation with IL-12 and IL-18 and requires the expression of GADD45?
Gene_expression (expression) of GADD45
5) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.04
Although data on the role and mode of activation of GADD45 proteins in T cells are still controversial, the regulation of the expression levels of GADD45 proteins constitutes an indirect additional mechanism to control the intensity and duration of p38 MAPK activation.
Gene_expression (expression) of GADD45 in T cells
6) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.04
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (transforming) of GADD45A
7) Confidence 0.26 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.39 Pain Relevance 0
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (expression) of GADD45A
8) Confidence 0.26 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.35 Pain Relevance 0
Several genes related to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, inhibitor of growth family member 5 (p28ING5), sphingosine-1-phosphate receptor 2 and somatostatin receptor 3.
Gene_expression (finger) of DNA-damage inducible beta in finger associated with aging and somatostatin
9) Confidence 0.13 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.66 Pain Relevance 0.12
Apoptosis induced by TRO in human MCF-7 breast carcinoma cells has been associated with induction of GADD45 gene expression [85] while growth inhibition has been correlated to overexpression of another DNA damage gene, GADD153, in nonsmall lung carcinoma cells [86].
Gene_expression (expression) of GADD45 gene in lung associated with lung cancer, breast cancer and apoptosis
10) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.77 Pain Relevance 0.04
part by stimulating the expression of the GADD 153 (for growth arrest and DNA damage-inducible gene-153) [36].
Gene_expression (expression) of GADD
11) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 1.00 Pain Relevance 0.04
proliferation in part by stimulating the expression of the GADD 153 (for growth arrest and DNA damage inducible gene-153)

[79].

Gene_expression (expression) of GADD
12) Confidence 0.02 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.74 Pain Relevance 0

General Comments

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