INT188120

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.60
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 27 75.56 Quite High
long-term potentiation 4 60.08 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 9 99.08 Very High Very High Very High
Alzheimer's Dementia 117 98.12 Very High Very High Very High
Disease 147 97.56 Very High Very High Very High
Disease Progression 12 94.24 High High
Targeted Disruption 129 88.48 High High
Cognitive Disorder 30 69.76 Quite High
Amyloidosis 3 50.00 Quite Low
Death 4 49.56 Quite Low
Attention Deficit Hyperactivity Disorder 15 23.76 Low Low
Amyloid Plaque 16 12.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results not only provide the first demonstration that partial suppression of BACE1 is effective in preventing cholinergic neurodegeneration associated with AD but also indicate that neurotoxic A?
Spec (partial) Regulation (effective) of Spec (partial) Negative_regulation (suppression) of BACE1 associated with disease
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.31 Pain Relevance 0.07
can limit the abilities of partial BACE1 reduction to suppress A?
Regulation (abilities) of Spec (partial) Negative_regulation (reduction) of BACE1
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.15 Pain Relevance 0
Studies from our laboratory and others applied genetic or immunization-based approaches to demonstrate that partial reduction of BACE1 suffices to attenuate A?
Spec (partial) Regulation (suffices) of Spec (partial) Negative_regulation (reduction) of BACE1 associated with immunization
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.86 Pain Relevance 0
ยท5XFAD mice, which would weaken the abilities of partial BACE1 reduction to suppress A?
Spec (partial) Regulation (abilities) of Spec (partial) Negative_regulation (reduction) of BACE1
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.50 Pain Relevance 0
-secretase inhibitors published to date show less strict regulation of A?
Regulation (regulation) of Negative_regulation (inhibitors) of secretase
5) Confidence 0.10 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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