INT188166

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.34
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 2
stromal cells 1
vertex 1
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 97.34 Very High Very High Very High
COX-2 inhibitor 5 95.40 Very High Very High Very High
imagery 26 89.76 High High
Inflammatory response 4 65.12 Quite High
antagonist 2 62.48 Quite High
anesthesia 2 52.08 Quite High
Pain 7 50.04 Quite High
analgesia 1 36.48 Quite Low
Paracetamol 2 35.12 Quite Low
Inflammation 19 31.56 Quite Low
Disease Link Frequency Relevance Heat
Cancer 54 98.40 Very High Very High Very High
Osteoarthritis 66 97.34 Very High Very High Very High
Osteoporosis 104 97.32 Very High Very High Very High
Osteogenic Sarcomas 3 97.00 Very High Very High Very High
Adhesions 46 95.40 Very High Very High Very High
Seminoma 12 94.20 High High
Embryonal Carcinoma 14 93.64 High High
Recurrence 2 93.52 High High
Scoliosis 1 93.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 88 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean cord PLAP activity was lower in elective cesarean deliveries than in spontaneous vertex deliveries (1.43 log10 ng/ml versus 1.82 log10 ng/ml, t = ?
Transcription (activity) of PLAP in vertex
1) Confidence 0.56 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1285069 Disease Relevance 0.64 Pain Relevance 0
In these cells, low concentrations of melatonin increased the mRNA levels of several genes expressed in osteoblasts including bone sialoprotein (BSP), alkaline phosphatase (ALP), osteopontin and osteocalcin.[15] Several studies using various animal models show that melatonin prevents bone deterioration including preventing idiopathic scoliosis in adolescents[1316] and that it stimulates proliferation of normal cells such as human bone cells.[13] However, there are no reports of melatonin effects on ADSC osteogenic differentiation.
Transcription (levels) of alkaline phosphatase in osteoblasts associated with scoliosis
2) Confidence 0.48 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.50 Pain Relevance 0.10
Quantitative RT-PCR analysis showed lower levels of OC and ALP mRNA in T-MPCs compared with BM-MPCs (Figure 3b).
Transcription (levels) of ALP
3) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.10 Pain Relevance 0
may not detect all ALP phenotypes if the epitope is absent (eg,
Neg (not) Transcription (detect) of ALP
4) Confidence 0.41 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.65 Pain Relevance 0
This

suggests that the immunoassay of PLAP/PLAP-like serum activity may

Transcription (activity) of PLAP
5) Confidence 0.41 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.95 Pain Relevance 0.07
In addition, to analyze the effects of bisphosphonates on osteogenic differentiation, we evaluated the mRNA expression of bone marker Alkaline Phosphatase (b-ALP) on stromal cells treated with Ris at different concentrations.
Transcription (expression) of ALP in stromal cells
6) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.49 Pain Relevance 0.09
m and adhered to the Ti substrate tightly, (ii) the adhesion strength of the coating layer on Ti was as high as about 30 MPa, (iii) the human osteoblastic cells cultured on the coatings produced by the combined method attached and proliferated favorably, and (iv) the cells on the coatings expressed significantly higher alkaline phosphatase activity than those on pure Ti, suggesting the stimulation of the osteoblastic activity on the coatings [207].
Transcription (expressed) of alkaline phosphatase associated with osteoporosis and adhesions
7) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2871132 Disease Relevance 0.29 Pain Relevance 0
g/mL), or both together on human OA subchondral bone osteoblasts, in the presence or absence of 1,25(OH)2D3 (vitamin D3) (50 nM), was determined on the bone biomarkers alkaline phosphatase and osteocalcin, on the expression (mRNA) and production (enzyme-linked immunosorbent assay) of bone remodelling factors OPG and RANKL, and on the pro-resorptive activity of these cells.
Transcription (expression) of alkaline phosphatase in osteoblasts associated with osteoarthritis
8) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.66 Pain Relevance 0.29
The maximal stimulatory effect on ALP was observed after 48 hours of treatment with 50 mM quercetin.
Transcription (observed) of ALP
9) Confidence 0.05 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2685048 Disease Relevance 0.06 Pain Relevance 0.06

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