INT188172

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A1)
Anatomy Link Frequency
basement membrane 1
COL4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 38.96 Quite Low
Inflammatory response 4 34.16 Quite Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cOX1 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Mechanotransduction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 120 99.64 Very High Very High Very High
Cancer 52 98.28 Very High Very High Very High
Neuroblastoma 50 97.96 Very High Very High Very High
Fracture Healing 128 93.04 High High
Shock 1 69.56 Quite High
Breast Cancer 1 68.48 Quite High
Lung Cancer 2 58.24 Quite High
Osteoporosis 6 51.64 Quite High
Pheochromocytoma 33 51.20 Quite High
Meningioma 3 42.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At higher concentrations of ATRA, the relative COL4A1 gene expression between leiomyoma and myometrial cells remained comparable.
Gene_expression (expression) of COL4A1 gene associated with uterine fibroids
1) Confidence 0.39 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.63 Pain Relevance 0
Arachnoid cells appear to express both epithelial and mesenchymal properties [36,44,45,49]; mesenchymal by their ability to express vimentin intermediate filaments and synthesize basement membrane proteins (collagen type I and IV, fibronectin, laminin) [37], and epithelial through the formation of cell-cell junctions [11].
Gene_expression (synthesize) of collagen type I and IV in basement membrane
2) Confidence 0.20 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
COL3A1 and COL4A1 were shown to be overexpressed in the PF7 and PF10 ESTs (Table 2).
Gene_expression (overexpressed) of COL4A1
3) Confidence 0.16 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.21 Pain Relevance 0
In addition, expression of HSP47 correlated with that of collagen I and IV.
Gene_expression (expression) of collagen I and IV
4) Confidence 0.11 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.35 Pain Relevance 0
Six of the eight genes in our dataset with prominent roles in angiogenesis (CSRP1, COL4A1, COL4A2, Perlecan, HDGF, Endoglin) were in cluster A.
Gene_expression (Six) of COL4A1
5) Confidence 0.06 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.15 Pain Relevance 0

General Comments

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