INT188173

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 3.17
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CDH5) plasma membrane (CDH5)
Anatomy Link Frequency
endothelial cells 3
tube 1
muscle tissue 1
lumen 1
tubule 1
CDH5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 87.16 High High
Nicotine 158 86.16 High High
Inflammatory stimuli 4 77.52 Quite High
imagery 32 67.84 Quite High
cva 50 48.24 Quite Low
headache 30 45.84 Quite Low
cytokine 14 6.80 Low Low
metalloproteinase 4 5.12 Low Low
tolerance 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 5 95.24 Very High Very High Very High
Adhesions 63 93.56 High High
Hypersensitivity 72 92.12 High High
Muscular Dystrophy 140 89.44 High High
Diabetes Mellitus 10 89.04 High High
Meningioma 30 87.92 High High
INFLAMMATION 54 87.16 High High
Hydrocele 28 85.44 High High
Lymphedema 49 84.88 Quite High
Nicotine Addiction 20 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 2,601 events that fell within R1 and were subsequently analyzed for VE-cadherin-PE expression, 2,308 (88.7%) also fell within gate M1 and were considered negative for VE-cadherin expression.
Spec (analyzed) Gene_expression (expression) of VE-cadherin-PE
1) Confidence 0.49 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.14 Pain Relevance 0
VE-cadherin-PE or CD31-FITC expression was assessed within labeled cell populations by comparing their fluorescent expression to unstained control cells.
Gene_expression (expression) of VE-cadherin-PE
2) Confidence 0.49 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.24 Pain Relevance 0
Of the 2,601 events that fell within R1 and were subsequently analyzed for VE-cadherin-PE expression, 2,308 (88.7%) also fell within gate M1 and were considered negative for VE-cadherin expression.
Gene_expression (expression) of VE-cadherin
3) Confidence 0.49 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.13 Pain Relevance 0
Several types have been described, including N-cadherin in neural and muscle tissue, P-cadherin in placental tissue, E-cadherin found in epithelial cells, and VE-cadherin expressed exclusively in endothelial cells [47,48].
Gene_expression (expressed) of VE-cadherin in neural
4) Confidence 0.49 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0
Flow cytometry analysis indicated that second and third passage cultures failed to express the endothelial cell markers CD31 or VE-cadherin in significant quantities, thereby showing that these cultures did not consist of endothelial cells from the venous sinus wall.


Neg (failed) Gene_expression (express) of VE-cadherin in endothelial cells
5) Confidence 0.38 Published 2005 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
The failure of these cultures to express the endothelial specific proteins CD31 and VE cadherin in significant quantities indicated that cells cultured from human AG explants were not significantly contaminated by endothelia from the venous sinus lumen.
Gene_expression (express) of VE cadherin in lumen
6) Confidence 0.38 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
In the following fluorescent analysis, cells falling within the predefined gate for intrinsic PE fluorescence were considered negative for VE-cadherin-PE expression.
Gene_expression (expression) of VE-cadherin-PE
7) Confidence 0.38 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0
Cells cultured from human AGs at second and third passage were labeled with the antibodies to VE-cadherin-PE or CD31-FITC and their expression of these endothelial markers was quantified using flow cytometry.
Gene_expression (expression) of VE-cadherin-PE
8) Confidence 0.38 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.16 Pain Relevance 0
For the VE-cadherin experiments cells were then incubated with an anti IgG1 PE secondary antibody (10 ?
Gene_expression (experiments) of VE-cadherin
9) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
OEC microarray data revealed high expression of VE-cadherin, claudin 11, claudin 5, caveolin 1 and caveolin 2 which was indicative of the presence of cell-cell specialized junctions and caveolae organelles.
Gene_expression (expression) of VE-cadherin
10) Confidence 0.34 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
Conventional RT-PCR at 30 cycles revealed marked higher expression of HLA-DRA, LYZ, and CD14 transcripts in eEPCs, while CAV1, VE-cadherin, and vWF transcripts were only present in OECs (Figure 3A).
Gene_expression (present) of VE-cadherin
11) Confidence 0.30 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.07 Pain Relevance 0.04
The PCA biplot analysis highlighted some differentially expressed genes for each group; eEPC genes included HLA-DRA, CD36, CD14, and complement 1QC, while OEC genes comprised caveolin1, VE-cadherin, CD34, and endothelial specific molecule 1, among others (Figure 1E).
Gene_expression (comprised) of VE-cadherin
12) Confidence 0.30 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.06 Pain Relevance 0.03
These progenitors were uniformly positive for endothelial markers CD146, thrombomodulin, VEGFR2, VE-cadherin, CD31, CD34, and typically showed greater proliferative potential than circulating endothelial cells.
Gene_expression (positive) of VE-cadherin in endothelial cells
13) Confidence 0.30 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.26 Pain Relevance 0.09
Quantitative analysis of total tubule formations expressing Ve-cadherin or CD31 antigens was performed with the AngioSys software (TCS CellWorks, Cat No.
Gene_expression (expressing) of Ve-cadherin in tubule
14) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.23 Pain Relevance 0
Under these conditions, we observed the formation of colonies with spindle-like cells expressing Ve-cadherin and CD31 endothelial markers from both normal and dystrophic CD133+CXCR4+CD34- cell populations.
Gene_expression (expressing) of Ve-cadherin
15) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.13 Pain Relevance 0
Several types have been described, including N-cadherin in neural and muscle tissue, P-cadherin in placental tissue, E-cadherin found in epithelial cells, and VE-cadherin expressed exclusively in endothelial cells [47,48].
Gene_expression (expressed) of VE-cadherin in muscle tissue
16) Confidence 0.17 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.27 Pain Relevance 0
After isolation, these hESC-ECs expressed endothelial specific markers such as vWF (96.3±1.4%), CD31 (97.2±2.5%), and VE-cadherin (93.7±2.8%), form vascular-like channels, and incorporated DiI-labeled acetylated low-density lipoprotein (DiI-Ac-LDL).
Spec (like) Gene_expression (expressed) of VE-cadherin
17) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737633 Disease Relevance 0.31 Pain Relevance 0.22
In order to study the phenotype of CD31+ cells thus obtained, we confirmed the endothelial phenotype of our CD31+ twice-purified hESC-ECs by flow cytometry analysis for the expression of vWF, CD31, and VE-cadherin (BD Biosciences), DiI-ac-LDL uptake assay, and Matrigel tube formation assay as previously described [15].


Gene_expression (expression) of VE-cadherin in tube
18) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.08 Pain Relevance 0
At the molecular level, doxycycline appeared to act on the adherence junction in the vasculature with increased expression of VE-cadherin, thus maintaining the cell junctions between endothelial cells and reducing their permeability.
Gene_expression (expression) of VE-cadherin in endothelial cells
19) Confidence 0.03 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 0.54 Pain Relevance 0.07

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