INT188196

Context Info Confidence 0.21 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 2.26 Pain Relevance 0.87

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)

LIF (Homo sapiens) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 236 81.64 Inflammation 52 75.00 Inflammatory mediators 32 71.20 agonist 4 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Leukemia 16 100.00 Carcinoma 64 95.52 INFLAMMATION 84 75.00 Lung Cancer 64 70.00 Metaplasia 32 5.00 Cancer 24 5.00 Cleidocranial Dysplasia 16 5.00 Malignant Neoplastic Disease 16 5.00 Carcinoma In Situ 8 5.00 Hyperplasia 4 5.00

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

In 43 paired cultures, the signalling through the signal transducer and activator of transcription (STAT) and extracellular regulated kinase (ERK) pathways and growth regulation by IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), interferon-?

leukemia inhibitory factor Regulation (regulation) of ERK associated with leukemia

1) Confidence 0.21 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.56 Pain Relevance 0.22

In 43 paired cultures, the signalling through the signal transducer and activator of transcription (STAT) and extracellular regulated kinase (ERK) pathways and growth regulation by IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), interferon-?

LIF Regulation (regulation) of ERK associated with leukemia

2) Confidence 0.21 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.56 Pain Relevance 0.22

In 43 paired cultures, the signalling through the signal transducer and activator of transcription (STAT) and extracellular regulated kinase (ERK) pathways and growth regulation by IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), interferon-?

LIF Regulation (regulation) of extracellular regulated kinase associated with leukemia

3) Confidence 0.18 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.57 Pain Relevance 0.22

In 43 paired cultures, the signalling through the signal transducer and activator of transcription (STAT) and extracellular regulated kinase (ERK) pathways and growth regulation by IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), interferon-?

leukemia inhibitory factor Regulation (regulation) of extracellular regulated kinase associated with leukemia

4) Confidence 0.18 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.57 Pain Relevance 0.22

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