INT188197

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
LIF (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 89.00 High High
agonist 1 77.44 Quite High
Inflammation 13 50.00 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 16 99.04 Very High Very High Very High
Lung Cancer 16 72.24 Quite High
INFLAMMATION 21 50.00 Quite Low
Small Cell Lung Carcinoma 1 23.36 Low Low
Malignant Neoplastic Disease 4 21.92 Low Low
Metaplasia 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Carcinoma In Situ 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In carcinoma cell lines, the major trends included a strong STAT3 activation by LIF (ADLC, H125), an increased (ADLC, H23) or decreased STAT3 activation by IL-6 (H125, H324), a decreased ERK activation by EGF (H522), and a treatment-independent, constitutive activation of the ERK pathway (H23).
LIF Positive_regulation (activation) of STAT3 associated with carcinoma
1) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.12

General Comments

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