INT188199

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) aging (IL6)
Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1)
Anatomy Link Frequency
epithelial cells 1
IL6 (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 98.02 Very High Very High Very High
agonist 1 84.48 Quite High
Inflammation 13 50.00 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 16 96.40 Very High Very High Very High
Lung Cancer 16 58.72 Quite High
INFLAMMATION 21 50.00 Quite Low
Small Cell Lung Carcinoma 1 30.40 Quite Low
Malignant Neoplastic Disease 4 28.96 Quite Low
Metaplasia 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Carcinoma In Situ 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cell lines responded to IL-6 cytokines like normal epithelial cells, but showed a detectable STAT3 signaling by LIF and a ~2-fold higher ERK activation by OSM and IL-6.
IL-6 Positive_regulation (activation) of ERK in epithelial cells associated with cytokine
1) Confidence 0.27 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.25 Pain Relevance 0.16

General Comments

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