INT188201

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM, STAT3) nucleoplasm (STAT3) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cytosol (STAT3)
Anatomy Link Frequency
epithelial cells 2
OSM (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 86.88 High High
agonist 1 63.04 Quite High
Inflammation 13 53.12 Quite High
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Carcinoma 1 66.56 Quite High
Malignant Neoplastic Disease 4 65.12 Quite High
Lung Cancer 16 58.52 Quite High
INFLAMMATION 21 53.12 Quite High
Carcinoma 16 25.44 Quite Low
Metaplasia 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Carcinoma In Situ 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In brief, normal type II epithelial cells showed the following features (Fig. 1A, top panel): OSM strongly activated phosphorylation of STAT3 and ERK, while IL-6 was less effective, and LIF did not produce any detectable response.
OSM Positive_regulation (activated) of Phosphorylation (phosphorylation) of STAT3 in epithelial cells
1) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.24 Pain Relevance 0.21

General Comments

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