INT188209

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
epithelial cells 1
OSM (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 98.02 Very High Very High Very High
agonist 2 84.48 Quite High
Inflammation 26 50.00 Quite Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 32 95.68 Very High Very High Very High
Metaplasia 16 74.64 Quite High
Cleidocranial Dysplasia 8 73.68 Quite High
Lung Cancer 32 58.00 Quite High
INFLAMMATION 42 50.00 Quite Low
Small Cell Lung Carcinoma 2 30.40 Quite Low
Malignant Neoplastic Disease 8 28.96 Quite Low
Cancer 12 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low
Carcinoma In Situ 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cell lines responded to IL-6 cytokines like normal epithelial cells, but showed a detectable STAT3 signaling by LIF and a ~2-fold higher ERK activation by OSM and IL-6.
OSM Positive_regulation (activation) of ERK in epithelial cells associated with cytokine
1) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.25 Pain Relevance 0.16
ERK activation by OSM was 108 ± 35%, by IL-6 was 31 ± 15%, and by EGF was 85 ± 40%.
OSM Positive_regulation (activation) of ERK
2) Confidence 0.30 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.22 Pain Relevance 0.11

General Comments

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