INT188215

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
epithelial cells 2
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 150 89.92 High High
Inflammation 109 50.00 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 96.04 Very High Very High Very High
Targeted Disruption 20 85.60 High High
Disease 17 54.88 Quite High
INFLAMMATION 124 50.00 Quite Low
Conjunctiva Disease 1 44.24 Quite Low
Hypersensitivity 9 41.64 Quite Low
Sprains And Strains 1 40.56 Quite Low
Rhinitis 11 40.00 Quite Low
Carcinoma 16 17.12 Low Low
Chromosome Aberrations 1 12.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
did not appreciably activate ERK and STAT3, but yielded highest level of STAT1 phosphorylation (2441 ± 2073% of OSM level (Fig. 4E &4F).
Negative_regulation (level) of Phosphorylation (phosphorylation) of STAT1
1) Confidence 0.31 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.07
In vitro this SNPs enhances the transcription of SOCS1 in human lung epithelial cells, but reduces phosphorylation of STAT1 stimulated with IFN-?
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of STAT1 in epithelial cells
2) Confidence 0.26 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.10

General Comments

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