INT188220

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.69
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
internal 1
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 295 91.60 High High
Inflammation 65 50.00 Quite Low
Inflammatory mediators 40 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 80 59.36 Quite High
Cleidocranial Dysplasia 20 58.80 Quite High
Metaplasia 40 58.36 Quite High
Cancer 30 58.32 Quite High
INFLAMMATION 105 50.00 Quite Low
Apoptosis 14 50.00 Quite Low
Chromosome Aberrations 5 11.88 Low Low
Lung Cancer 80 5.00 Very Low Very Low Very Low
Leukemia 20 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
did not appreciably activate ERK and STAT3, but yielded highest level of STAT1 phosphorylation (2441 ± 2073% of OSM level (Fig. 4E &4F).
Phosphorylation (phosphorylation) of OSM
1) Confidence 0.59 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.07
STAT3 phosphorylation by OSM and IL-6, and STAT1 phosphorylation by OSM, IL-6 and IFN?
Phosphorylation (phosphorylation) of OSM
2) Confidence 0.52 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.23 Pain Relevance 0.06
STAT3 phosphorylation by OSM and IL-6, and STAT1 phosphorylation by OSM, IL-6 and IFN?
Phosphorylation (phosphorylation) of OSM
3) Confidence 0.52 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.23 Pain Relevance 0.06
To compare the responses between normal and abnormal epithelial cell cultures from individual donors, as well the responses among different donors, the OSM-induced phosphorylation of STAT1, STAT3 and ERK1/2 in the normal cell cultures of each paired set was used as an internal reference (defined as 100).
Phosphorylation (phosphorylation) of OSM in internal
4) Confidence 0.52 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.03
STAT3 phosphorylation by OSM and IL-6, and STAT1 phosphorylation by OSM, IL-6 and IFN?
Phosphorylation (phosphorylation) of OSM
5) Confidence 0.52 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.23 Pain Relevance 0.03
The dimeric interface is therefore mutually exclusive from the phospholipid and OSM binding surface.
Phosphorylation (phospholipid) of OSM
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

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