INT188222

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 106 76.48 Quite High
Inflammation 41 75.00 Quite High
Inflammatory mediators 8 45.64 Quite Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 16 89.92 High High
Leukemia 4 84.44 Quite High
INFLAMMATION 57 75.00 Quite High
Carcinoma 16 69.96 Quite High
Infection 14 5.00 Very Low Very Low Very Low
Premature Birth 9 5.00 Very Low Very Low Very Low
Metaplasia 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Pre-term Labor 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In preneoplastic cells, the aberrant signaling that was detected most frequently was an elevated activation of ERK, a reduced or increased IL-6 and EGF response, and an increased LIF response.
Positive_regulation (increased) of Regulation (response) of IL-6
1) Confidence 0.29 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.51 Pain Relevance 0.13
These results show that LPS treatment of only the amniotic side of the gestational membranes stimulated a similar IL-6 response on the amniotic and choriodecidual sides of the membranes, but that the converse was not true for LPS treatment of only the choriodecidual side which stimulated increased IL-6 release on the choriodecidual side only.


Positive_regulation (stimulated) of Regulation (response) of IL-6
2) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0

General Comments

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