INT188230

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6ST) extracellular region (IL6ST) plasma membrane (IL6ST)
Anatomy Link Frequency
kidney 1
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 97.22 Very High Very High Very High
Arthritis 70 73.44 Quite High
anakinra 5 67.40 Quite High
Pain 1 66.16 Quite High
Inflammation 19 56.64 Quite High
rheumatoid arthritis 15 41.52 Quite Low
corticosteroid 8 40.16 Quite Low
antagonist 2 35.36 Quite Low
methotrexate 6 13.96 Low Low
cINOD 2 11.88 Low Low
Disease Link Frequency Relevance Heat
Leukemia 5 85.16 High High
Exanthema 2 82.84 Quite High
Fever 7 82.36 Quite High
Juvenile Chronic Polyarthritis 63 73.44 Quite High
INFLAMMATION 31 56.64 Quite High
Metaplasia 8 46.92 Quite Low
Experimental Arthritis 1 44.96 Quite Low
Rheumatoid Arthritis 15 41.52 Quite Low
Adhesions 2 34.24 Quite Low
Disease 29 33.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of IL6ST, a component of the functional receptors for LIF and OSM, leads to developmental defects in the kidney [53,54].
Negative_regulation (Inactivation) of IL6ST in kidney
1) Confidence 0.33 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
Reduction of signaling by IL-6 cytokines has been associated with treatment-induced receptor protein down regulation [16,25], expression of signal modifying SOCS proteins [26] or desensitization of gp130 [27].
Negative_regulation (desensitization) of gp130 associated with cytokine
2) Confidence 0.23 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.06 Pain Relevance 0.23
Since the gp130 homodimer is shared among other receptors than for IL-6, the blockade of gp130 may implicate a wide range of undesirable effects.
Negative_regulation (blockade) of gp130
3) Confidence 0.17 Published 2010 Journal Core evidence Section Body Doc Link PMC2899792 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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