INT188232

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.57
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
epithelial cells 2
lung 2
mesoderm 1
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 230 99.04 Very High Very High Very High
Inflammation 75 98.64 Very High Very High Very High
Osteoarthritis 54 88.04 High High
Etanercept 8 80.08 Quite High
agonist 7 64.80 Quite High
Inflammatory mediators 24 34.56 Quite Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 109 98.64 Very High Very High Very High
Lung Cancer 48 98.44 Very High Very High Very High
Leukemia 14 93.36 High High
Osteoarthritis 57 88.04 High High
Cancer 101 86.48 High High
Carcinoma 52 85.44 High High
Necrosis 6 68.68 Quite High
Metaplasia 24 48.24 Quite Low
Cleidocranial Dysplasia 12 42.96 Quite Low
Stress Incontinence 8 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the substantial changes in response patterns, STAT and ERK signaling in response to OSM was consistently high in all analyzed lung cancer cell lines.
Positive_regulation (response) of OSM in lung associated with lung cancer
1) Confidence 0.41 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.17
To relate cytokine signaling with effects on cell proliferation, representative lung cell types were cultured for 6 days in growth medium containing in addition increasing concentrations of OSM, IL-6 or LIF (Fig. 2).
Positive_regulation (increasing) of OSM in lung associated with cytokine
2) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.21 Pain Relevance 0.12
The potential arsenic biomarker set is composed of transcripts for the CXL1, DUSP1, EGR-1, IER2, JUNB, MIRN21, OSM, PTGS2, RNF149, SFRS5, and SOC3 genes (Table 1).
Positive_regulation (composed) of OSM
3) Confidence 0.38 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0 Pain Relevance 0
Among the abnormal epithelial cells with elevated basal ERK phosphorylation (Fig. 4B), the two cell cultures from metaplastic foci in the airway were distinct because the basal ERK phosphorylation that was equivalent to the OSM-treated control culture (Fig. 5A).
Positive_regulation (equivalent) of OSM in epithelial cells
4) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.09 Pain Relevance 0
and OSM were increased.
Positive_regulation (increased) of OSM
5) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911907 Disease Relevance 0.82 Pain Relevance 0.65
The activation of these receptors by their respective ligands (LIF and OSM, two members of the IL6 family) induces the interconversion between metanephros mesoderm and epithelium in the urinary tract [53,54].
Positive_regulation (activation) of OSM in mesoderm
6) Confidence 0.26 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
The activation of these receptors by their respective ligands (LIF and OSM, two members of the IL6 family) induces the interconversion between metanephros mesoderm and epithelium in the urinary tract [53,54].
Positive_regulation (activation) of OSM in epithelium
7) Confidence 0.09 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0

General Comments

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