INT188239

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 6.58
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (LMNA) nuclear envelope (LMNA) structural molecule activity (LMNA)
nucleus (LMNA) cytoplasm (LMNA)
Anatomy Link Frequency
band 4
brain 1
myotubes 1
patterning 1
neural 1
LMNA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 65.68 Quite High
Hippocampus 26 64.56 Quite High
Action potential 34 51.44 Quite High
alcohol 4 42.76 Quite Low
Angina 5 38.72 Quite Low
Calcium channel 2 38.64 Quite Low
cva 4 35.24 Quite Low
primary somatosensory cortex 54 5.00 Very Low Very Low Very Low
Pyramidal cell 24 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 145 100.00 Very High Very High Very High
Dilated Cardiomyopathy 137 99.24 Very High Very High Very High
Heart Disease 9 99.20 Very High Very High Very High
Heart Rate Under Development 38 96.92 Very High Very High Very High
Malignant Neoplastic Disease 24 95.88 Very High Very High Very High
Sudden Cardiac Death 28 95.20 Very High Very High Very High
Congenital Anomalies 15 94.48 High High
Coronary Artery Disease 47 93.64 High High
Muscular Dystrophy 70 93.48 High High
Arrhythmias 2 Under Development 9 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lamin interacts directly with the chromatin and also with the integral proteins of the inner nuclear membrane, thereby playing a role in maintaining the structural integrity and spatial organization of other inner nuclear membrane.
Lamin Binding (interacts) of
1) Confidence 0.47 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 1.27 Pain Relevance 0
It has been argued that the gamma components of the LFP are bound to the scale of a column (Liu and Newsome 2006; Katzner et al. 2009; but see Berens et al. 2008).
LFP Binding (bound) of
2) Confidence 0.46 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
One obstacle to investigating the influence of the electric field associated with the LFP is that it is technically challenging to experimentally manipulate the fields, to test for effects on network function because of the complex spatial structures of endogenous fields and the filtering characteristics of brain tissue (Bédard et al., 2004; Logothetis et al., 2007).
LFP Binding (associated) of in brain
3) Confidence 0.46 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876880 Disease Relevance 0 Pain Relevance 0.06
Here we instead ask whether currents associated with the LFP can influence neural dynamics and participate in neural computation via field effects (Jefferys, 1995; Bullock, 1997).
LFP Binding (associated) of in neural
4) Confidence 0.41 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876880 Disease Relevance 0 Pain Relevance 0.06
After 14 days of culture, the presence of chimeric human/murine myotubes was evaluated by immunostaining for desmin, slow myosin heavy chain (MyHCs) and human lamin A/C.
lamin A/C Binding (immunostaining) of in myotubes
5) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.30 Pain Relevance 0.03
However, lamin A/C (LMNA) is the most frequent disease associated gene for familial DCM with conduction system disease.
lamin A/C Binding (associated) of associated with dilated cardiomyopathy and disease
6) Confidence 0.35 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 1.24 Pain Relevance 0
However, lamin A/C (LMNA) is the most frequent disease associated gene for familial DCM with conduction system disease.
LMNA Binding (associated) of associated with dilated cardiomyopathy and disease
7) Confidence 0.34 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 1.24 Pain Relevance 0
Actually, in responses to the plaids, there was a clear dissociation in the oscillatory patterning between the LFP and MUA.
LFP Spec (clear) Binding (dissociation) of in patterning
8) Confidence 0.31 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
Recently, Palanca and DeAngelis (2005) have used coherence analysis of the MUA and LFP to test for binding of oriented contours in area MT.
LFP Binding (binding) of
9) Confidence 0.31 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
Directional information in LFP and SUA
LFP Binding (information) of
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0
However, despite the progress made to date on using LFP to extract information about response direction, the decoding power obtained using simultaneously recorded LFP, which is what would be required for effective BMI applications, has been relatively modest (?
LFP Binding (recorded) of
11) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0
Therefore, it is highly recommended to screen LMNA for genetic variants when such clinical features are present in a DCM patient.
LMNA Binding (screen) of associated with dilated cardiomyopathy
12) Confidence 0.31 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 1.56 Pain Relevance 0
LMNA genotyping
LMNA Binding (genotyping) of
13) Confidence 0.30 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1289285 Disease Relevance 0.58 Pain Relevance 0
LFP direction by contrast showed no consistent peak, although values were significant across a broad frequency range (Figures 4C,D).
LFP Binding (direction) of
14) Confidence 0.27 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0
Such a difference in the signal : noise ratio with which oscillations were recorded almost certainly underlies the differences in unit to M1 LFP coherence observed between the two animals.


LFP Binding (underlies) of
15) Confidence 0.20 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228402 Disease Relevance 0 Pain Relevance 0
Both areas showed clear peaks in their average unit to local LFP coherence spectra (Fig. 6, Ai and ii), and in their average unit to M1 LFP coherence spectra (Fig. 6, Bi and ii).
LFP Spec (clear) Binding (unit) of
16) Confidence 0.20 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228402 Disease Relevance 0 Pain Relevance 0
Alternatively, because coherence is a signal : noise measure, the lower coherence in monkey M could result from poorer quality recordings of M1 LFP from the microwire electrodes ?
LFP Binding (recordings) of
17) Confidence 0.18 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228402 Disease Relevance 0.09 Pain Relevance 0
A linear mixed-model regression of LFP responses shows that all factors and their interactions are statistically significant (Table 1).
LFP Binding (interactions) of
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886052 Disease Relevance 0.31 Pain Relevance 0.03
However, the pattern of NTE changes between movie and spontaneous condition for local causal interactions (Fig. 4(a)) were in most cases consistent with the case of distant interactions: for example we found that interactions between the two LFP gamma bands, and between gamma LFPs and lower-frequency LFP bands also increased during movie presentation.
LFP Binding (interactions) of in bands
19) Confidence 0.02 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2978901 Disease Relevance 0 Pain Relevance 0
On the other hand, some causal interactions both within lower frequencies (low LFP and theta) and within higher frequencies (gamma and MUA) were far from their bootstrap distribution and were thus highly significant.
LFP Binding (interactions) of
20) Confidence 0.02 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2978901 Disease Relevance 0 Pain Relevance 0

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