INT18825

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.00
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRLR) plasma membrane (PRLR)
Anatomy Link Frequency
tail 1
developmental stage 1
PRLR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 22 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
Morphine 4 99.84 Very High Very High Very High
Dynorphin 1 99.80 Very High Very High Very High
Enkephalin 2 99.72 Very High Very High Very High
opioid receptor 8 99.62 Very High Very High Very High
antinociception 1 98.84 Very High Very High Very High
tail-flick 1 96.84 Very High Very High Very High
Antinociceptive 2 96.48 Very High Very High Very High
Spinal cord 4 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Galactorrhea 47 100.00 Very High Very High Very High
Disease 10 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 51 94.36 High High
Hypersensitivity 5 91.92 High High
Cocaine Dependence 2 75.00 Quite High
Reprotox - General 1 2 68.12 Quite High
Congenital Anomalies 6 67.36 Quite High
Lymphatic System Cancer 1 52.40 Quite High
Erythrocytosis 11 50.00 Quite Low
Prolactinoma 2 36.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a statistically significant positive correlation between serum PRL levels and disease activity and HPRL and disease activity as measured by the SLEDAI.
Gene_expression (levels) of HPRL associated with galactorrhea and disease
1) Confidence 0.40 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 1.83 Pain Relevance 0
For each developmental stage, we have compared the expression pattern of kappa receptors with that of mu and delta receptor subtypes.
Gene_expression (expression) of delta receptor in developmental stage
2) Confidence 0.09 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2161716 Disease Relevance 0 Pain Relevance 0.44
These findings were confirmed in the antinociceptive tests (tail-flick and acetic acid writhing) in mice, which demonstrated that cyclorphan (3a) produced antinociception that was mediated by the delta receptor while 3b did not produce agonist or antagonist effects at the delta receptor.
Neg (not) Gene_expression (produce) of delta receptor in tail associated with antinociception, antagonist, agonist, tail-flick and antinociceptive
3) Confidence 0.03 Published 2000 Journal J. Med. Chem. Section Abstract Doc Link 10633042 Disease Relevance 0.07 Pain Relevance 0.82
Both peptides were selective for delta receptor.
Gene_expression (selective) of delta receptor
4) Confidence 0.02 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11741591 Disease Relevance 0 Pain Relevance 0.30
As shown in Figure 5A, transfection of the truncated receptor induced a number of biochemical changes (i.e. receptor autophosphorylation and STAT5 phosphorylation), even in the absence of exogenously added EPO, suggesting the possibility of autoactivation and/or hypersensitivity of receptor.
Gene_expression (transfection) of truncated receptor associated with hypersensitivity
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.09 Pain Relevance 0
Morphine was used as a mu-receptor agonist, D-Ala-D-Leu-Enkephalin (DADLE) as a delta-receptor agonist and dynorphin 1-13 (Dyn) as a kappa-receptor agonist.
Gene_expression (agonist) of delta-receptor associated with dynorphin, agonist, enkephalin and morphine
6) Confidence 0.01 Published 1990 Journal Neurochem. Res. Section Abstract Doc Link 1982460 Disease Relevance 0 Pain Relevance 0.97
We used the method of reverse transcription-polymerase chain reaction (RT-PCR) to observe the effects of long-term administration of peptide delta opioid receptor agonist DPDPE and non-peptide delta agonist BW373U86 on the mRNA expression of delta receptor and the possible difference between the two agonists.
Gene_expression (expression) of delta receptor associated with agonist and opioid receptor
7) Confidence 0.00 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.49
We have reinvestigated the question of whether internalization is obligatory for MAPK activation by opioid receptors, using cell lines expressing the cloned mu or delta receptor.
Gene_expression (expressing) of delta receptor associated with opioid receptor
8) Confidence 0.00 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10884553 Disease Relevance 0 Pain Relevance 0.45

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