INT188251

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.26
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DKK1) extracellular space (DKK1) extracellular region (DKK1)
plasma membrane (DKK1) signal transducer activity (DKK1)
DKK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 17 100.00 Very High Very High Very High
Osteoarthritis 70 77.28 Quite High
cINOD 6 72.40 Quite High
Arthritis 2 70.32 Quite High
Action potential 3 69.76 Quite High
beta blocker 1 52.48 Quite High
aspirin 2 51.76 Quite High
rheumatoid arthritis 2 49.28 Quite Low
Pain 3 44.16 Quite Low
metalloproteinase 3 26.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 82 99.46 Very High Very High Very High
Arrhythmias 2 Under Development 1 98.48 Very High Very High Very High
Hemorrhage 5 98.24 Very High Very High Very High
Coronary Heart Disease 1 96.96 Very High Very High Very High
Stroke 5 91.76 High High
Myocardial Infarction 18 85.76 High High
Osteoarthritis 70 77.28 Quite High
Obesity 11 75.00 Quite High
Pressure Volume 2 Under Development 9 73.32 Quite High
Aging 2 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Wnt-Frizzled interaction can be antagonized by several secreted proteins, including Dickkopf1 (Dkk1), Wnt inhibitory factor 1(WIF-1) and secreted frizzled-related protein (sFRP) family members.
Localization (secreted) of Dickkopf1
1) Confidence 0.50 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.43 Pain Relevance 0.19
-catenin pathway can become the potential therapeutic target of cancer achieved by expression of secreted antagonists of the pathway, such as Dkk1.
Localization (secreted) of Dkk1 associated with cancer and antagonist
2) Confidence 0.50 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.41 Pain Relevance 0.18
The Wnt-Frizzled interaction can be antagonized by several secreted proteins, including Dickkopf1 (Dkk1), Wnt inhibitory factor 1(WIF-1) and secreted frizzled-related protein (sFRP) family members.
Localization (secreted) of Dkk1
3) Confidence 0.50 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.43 Pain Relevance 0.19
Dickkopf-1 (Dkk-1) is a secreted protein that has been defined as a direct inhibitor of Wnt/?
Localization (secreted) of Dickkopf-1
4) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.91 Pain Relevance 0.14
Patients treated earlier after coronary occlusion, when risk is greatest, are more likely to develop ventricular fibrillation [19], which can explain why arrhythmias were more frequent in patients who received SK ?
Localization (received) of SK associated with arrhythmias 2 under development and coronary heart disease
5) Confidence 0.30 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 0.96 Pain Relevance 0.05
The negatively regulated genes included FAS, TNFR, COL6A1, JAM2, FOXQ1, FOXO1, NESTIN, SMAD3, SLIT3, DKK1, WNT5A, BMP1, and GLIS3 which are implicated in differentiation processes as well as a number of novel genes.
Localization (implicated) of DKK1
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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