INT188252

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.94
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DKK1) extracellular space (DKK1) extracellular region (DKK1)
plasma membrane (DKK1) signal transducer activity (DKK1)
DKK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 4 80.28 Quite High
cva 7 69.76 Quite High
headache 2 35.44 Quite Low
Pain 3 34.36 Quite Low
beta blocker 2 31.48 Quite Low
aspirin 4 30.76 Quite Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 12 98.16 Very High Very High Very High
Adverse Drug Reaction 76 96.80 Very High Very High Very High
Osteoporosis 46 95.12 Very High Very High Very High
Stroke 10 91.04 High High
Hemorrhage 13 85.68 High High
Cancer 4 81.36 Quite High
Pressure Volume 2 Under Development 18 80.80 Quite High
Vomiting 10 78.48 Quite High
Arrhythmias 2 Under Development 2 75.96 Quite High
Coronary Heart Disease 2 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-responders also had elevated or stable DKK-1 levels.
Positive_regulation (elevated) of DKK-1
1) Confidence 0.41 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.59 Pain Relevance 0
Following rSK administration, a significant increase of anti-SK antibodies binding and neutralization titers persisting for 6 months or more have been described [7].
Positive_regulation (increase) of anti-SK
2) Confidence 0.23 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 1.02 Pain Relevance 0
Patients who received SK ?
Positive_regulation (received) of SK
3) Confidence 0.20 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 1.33 Pain Relevance 0.08
Dkk-1 is up-regulated > 6-fold in ESE vs.
Positive_regulation (regulated) of Dkk-1
4) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0 Pain Relevance 0

General Comments

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