INT188255

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 12.69
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DKK1) extracellular space (DKK1) extracellular region (DKK1)
plasma membrane (DKK1) signal transducer activity (DKK1)
Anatomy Link Frequency
colon 2
small intestine 2
urine 2
stem cell 1
stem 1
DKK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
cytokine 4 98.86 Very High Very High Very High
Inflammation 108 82.24 Quite High
spinal inflammation 76 81.32 Quite High
Osteoarthritis 70 77.28 Quite High
imagery 39 76.40 Quite High
Arthritis 2 75.12 Quite High
cINOD 5 73.32 Quite High
Crohn's disease 320 68.60 Quite High
withdrawal 5 68.48 Quite High
Disease Link Frequency Relevance Heat
Mesothelioma 316 100.00 Very High Very High Very High
Repression 4 100.00 Very High Very High Very High
Cancer 298 99.74 Very High Very High Very High
Malignant Neoplastic Disease 49 98.96 Very High Very High Very High
Death 24 98.60 Very High Very High Very High
Osteophyte 7 98.12 Very High Very High Very High
Adverse Drug Reaction 114 97.94 Very High Very High Very High
Hypercalcemia 18 97.76 Very High Very High Very High
Osteogenic Sarcomas 12 97.72 Very High Very High Very High
Myocardial Infarction 54 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate bone resorption, we measured urine NTX-I (Ostex International, Seattle, WA, USA) by competitive enzyme immunoassay techniques. bALP, PINP, DKK-1 and NTX-I were all analyzed in duplicates.
Gene_expression (bALP) of DKK-1 in urine associated with hypercalcemia
1) Confidence 0.60 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.25 Pain Relevance 0
Changes in serum or urine levels of bALP, PINP, DKK-1, NTX-I, PTH and calcium were analyzed by comparison of the value of each marker at a given time point with the same marker pre-treatment using a Wilcoxon signed rank test.
Gene_expression (levels) of DKK-1 in urine
2) Confidence 0.54 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
-catenin pathway can become the potential therapeutic target of cancer achieved by expression of secreted antagonists of the pathway, such as Dkk1.
Gene_expression (expression) of Dkk1 associated with cancer and antagonist
3) Confidence 0.45 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.41 Pain Relevance 0.18
The Wnt-Frizzled interaction can be antagonized by several secreted proteins, including Dickkopf1 (Dkk1), Wnt inhibitory factor 1(WIF-1) and secreted frizzled-related protein (sFRP) family members.
Gene_expression (antagonized) of Dkk1
4) Confidence 0.45 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.44 Pain Relevance 0.19
A SK produced by recombinant DNA techniques (rSK) has been evaluated previously in clinical trials in AMI patients.
Gene_expression (produced) of SK associated with myocardial infarction
5) Confidence 0.31 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 0.37 Pain Relevance 0
MM cell cultures expressed high mRNA levels of the mesothelioma markers mesothelin (MSLN), calretinin (CALB2), the WNT1 antagonist DKK1 and the stem cell marker BMI-1.
Gene_expression (expressed) of DKK1 in stem cell associated with mesothelioma and antagonist
6) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 0.65 Pain Relevance 0.05
Our cell cultures express DKK1 at high levels, like other tumors such as Wilms' tumor, osteosarcomas, hepatocellular carcinomas and prostate cancer [34-36].
Gene_expression (express) of DKK1 associated with cancer, hepatocellular cancer, osteogenic sarcomas and reprotox - general 1
7) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 1.45 Pain Relevance 0
By real time PCR we found that our cell lines expressed high mRNA levels of typical mesothelioma markers as mesothelin (MSLN) and calretinin (CALB2), and of BMI-1, a stemness marker, and DKK1, a potent Wingless [WNT] inhibitor.


Gene_expression (expressed) of DKK1 associated with mesothelioma
8) Confidence 0.29 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2850899 Disease Relevance 0.73 Pain Relevance 0
Thus, the inhibitory effect of DKK1 would maintain stemness and inappropriate persistent DKK1 and BMI-1 expression would ultimately lead to malignant transformation, by keeping the cells in an undifferentiated, "stem-like" cellular state.


Gene_expression (expression) of DKK1 in stem associated with malignant neoplastic disease
9) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 0.76 Pain Relevance 0
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (expressing) of Dkk1 in colon associated with antagonist and repression
10) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.72 Pain Relevance 0.21
Dickkopf-1 (Dkk-1) is a secreted protein that has been defined as a direct inhibitor of Wnt/?
Gene_expression (/) of Dickkopf-1
11) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.98 Pain Relevance 0.17
Individual analysis for each suspected ADR showed that arrhythmias were the most time-influenced, being more frequent this event in patients who received SK ?
Gene_expression (received) of SK associated with adverse drug reaction
12) Confidence 0.27 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 1.56 Pain Relevance 0.06
Patient demographics, time between symptom onset and SK infusion, concomitant therapy, outcome (if death and cause of death) and ADR description, including duration, severity, treatment and need for discontinuation, were documented.
Gene_expression (infusion) of SK associated with adverse drug reaction and death
13) Confidence 0.27 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1291362 Disease Relevance 1.03 Pain Relevance 0
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (repression) of Dkk1 in colon associated with antagonist and repression
14) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.75 Pain Relevance 0.22
TNF and other proinflammatory cytokines are known to promote bone formation by upregulating the expression of Dickkopf-1, a key target gene of TNF and an inhibitor of osteophyte regulators [29].
Gene_expression (expression) of Dickkopf-1 associated with osteophyte and cytokine
15) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 1.14 Pain Relevance 0.82
Much of this research assumes that TK can be imposed upon a SK classification of living things.
Gene_expression (imposed) of SK
16) Confidence 0.12 Published 2010 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2828978 Disease Relevance 0 Pain Relevance 0
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (expressing) of Dkk1 in small intestine associated with antagonist and repression
17) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.72 Pain Relevance 0.21
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (repression) of Dkk1 in small intestine associated with antagonist and repression
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.75 Pain Relevance 0.22
1 inhibits expression of DKK-1 mRNA in a SMAD-independent manner [19].
Gene_expression (expression) of DKK-1 mRNA
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0.07

General Comments

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