INT188282

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 10.08
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
testis 2
pituitary 2
neutrophil 2
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 190 100.00 Very High Very High Very High
nud 27 99.66 Very High Very High Very High
Pain 11 99.34 Very High Very High Very High
antagonist 22 94.96 High High
addiction 2 86.96 High High
tolerance 4 83.04 Quite High
Eae 9 82.32 Quite High
antidepressant 12 80.16 Quite High
Somatostatin 7 79.76 Quite High
transdermal 2 76.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 192 100.00 Very High Very High Very High
Dyspepsia 27 99.66 Very High Very High Very High
Infection 150 99.64 Very High Very High Very High
Pain 11 99.34 Very High Very High Very High
Ulcers 120 99.26 Very High Very High Very High
Stomach Cancer 20 99.08 Very High Very High Very High
Stress 39 96.60 Very High Very High Very High
Obesity 178 96.40 Very High Very High Very High
Disease 26 95.84 Very High Very High Very High
Gastritis 60 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, these studies did not control for gastrointestinal symptoms such as pain and indigestion, which may also affect appetite and ghrelin production (13).
Spec (may) Regulation (affect) of Gene_expression (production) of ghrelin associated with pain and nud
1) Confidence 0.31 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 1.03 Pain Relevance 0.28
To elucidate the effects of H. pylori eradication on ghrelin production, more sophisticated investigations controlling these biases are needed.
Regulation (effects) of Gene_expression (production) of ghrelin
2) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 1.01 Pain Relevance 0.28
Our study was designed to evaluate the change in ghrelin production at 4 weeks after H. pylori eradication and therefore was too short to detect a change in BMI.
Regulation (change) of Gene_expression (production) of ghrelin associated with obesity
3) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.96 Pain Relevance 0.11
So the change in ghrelin production by H. pylori eradication in these previous studies might be biased by the severe inflammation of these diseases.
Regulation (change) of Gene_expression (production) of ghrelin associated with inflammation and disease
4) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 1.54 Pain Relevance 0.19
It has been suggested that the expression of ghrelin peptide in mature Leydig cells in the rat testis is under the hormonal regulation of pituitary LH [12].
Regulation (under) of Gene_expression (expression) of ghrelin in pituitary
5) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Caminos et al. [13] found dynamic changes in the profile of ghrelin expression during the oestrous cycle and throughout pregnancy in rats, suggesting a precise regulation of ovarian expression of ghrelin.
Regulation (changes) of Gene_expression (expression) of ghrelin
6) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Caminos et al. [13] found dynamic changes in the profile of ghrelin expression during the oestrous cycle and throughout pregnancy in rats, suggesting a precise regulation of ovarian expression of ghrelin.
Regulation (regulation) of Gene_expression (expression) of ghrelin
7) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.11 Pain Relevance 0
We are aware of only one other study that examines the effects on mood of manipulations to ghrelin expression [15].
Spec (examines) Regulation (effects) of Gene_expression (expression) of ghrelin
8) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915752 Disease Relevance 0.64 Pain Relevance 0.22
Chronic GH excess or deficiency and exercise also do not consistently modify ghrelin production in humans or animals [118–120].
Neg (not) Regulation (modify) of Gene_expression (production) of ghrelin
9) Confidence 0.15 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.39 Pain Relevance 0.24
Our strategy was to combine all available information from previous literature, in order to provide a complete structured review on the prokinetic properties of exogenous ghrelin and its potential use for treatment of
Regulation (review) of Gene_expression (properties) of ghrelin
10) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Abstract Doc Link PMC2915793 Disease Relevance 0.09 Pain Relevance 0.03
Because ulcer healing is another important factor affecting appetite and ghrelin production, as suggested by our previous study (17) and can act as a bias in this study, we recruited only healthy volunteers not having peptic ulcers.
Regulation (affecting) of Gene_expression (production) of ghrelin associated with ulcers
11) Confidence 0.14 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.75 Pain Relevance 0
Because inflammation influences ghrelin production (12), the relationship between H. pylori eradication and ghrelin production might have been biased by these inflammatory changes.
Regulation (influences) of Gene_expression (production) of ghrelin associated with inflammation
12) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 1.31 Pain Relevance 0.27
We assessed the effect of inflammatory changes on ghrelin production by the gastric mucosa.
Regulation (changes) of Gene_expression (production) of ghrelin associated with inflammation
13) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.08
We assessed the effect of inflammatory changes on ghrelin production by the gastric mucosa.
Regulation (effect) of Gene_expression (production) of ghrelin associated with inflammation
14) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.08
Some authors suggest that inflammation of the gastric mucosa is the one of the important mechanisms of H. pylori induced change of ghrelin production.
Regulation (change) of Gene_expression (production) of ghrelin associated with inflammation
15) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 1.49 Pain Relevance 0.16
Multiple regression analysis was used to assess the effects of H. pylori eradication on ghrelin production by the gastric mucosa, adjusted by the weight change and change in neutrophil or mononuclear cell infiltration.
Regulation (effects) of Gene_expression (production) of ghrelin in neutrophil
16) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.22 Pain Relevance 0
In addition, the data indicate that testicular expression of ghrelin and its receptor is physiologically regulated in the adult and developmentally regulated in the fetus.
Regulation (regulated) of Gene_expression (expression) of ghrelin
17) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
In addition, we examined whether (a) ghrelin and GHSR-1a protein expression is developmentally or physiologically regulated in the adult and fetal ovine testis and (b) ghrelin expression is linked to proliferative activity in the developing fetal testis.


Spec (whether) Regulation (regulated) of Gene_expression (expression) of ghrelin in testis
18) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.07 Pain Relevance 0
In addition, the data indicate that testicular expression of ghrelin and its receptor is physiologically regulated in the adult and developmentally regulated in the fetus.
Regulation (regulated) of Gene_expression (expression) of ghrelin
19) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0

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