INT188284

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
interstitial cells 2
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 39 65.72 Quite High
Inflammation 31 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 4 91.12 High High
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 32 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Hyperplasia 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From day 70 onwards, positive staining for GHSR-1a was restricted to the Sertoli and interstitial cells (Fig. 6j,n)
Negative_regulation (positive) of Gene_expression (staining) of GHSR in interstitial cells
1) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
GHS-R expression is also high in fetal and neonatal life, decreases postnatally and increases again just before puberty to decrease again later (413).
Negative_regulation (decreases) of Gene_expression (expression) of GHS-R
2) Confidence 0.15 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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