INT188286

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.64
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Pou1f1) nucleus (Pou1f1) DNA binding (Pou1f1)
transcription factor binding (Pou1f1) cytoplasm (Pou1f1)
Anatomy Link Frequency
pituitary 2
Pit 2
Pou1f1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 56 98.08 Very High Very High Very High
Enkephalin 6 94.44 High High
dopamine receptor 4 92.96 High High
Dopamine 26 64.48 Quite High
Central nervous system 2 58.08 Quite High
medulla 4 51.04 Quite High
Neurotransmitter 16 45.40 Quite Low
gABA 30 30.24 Quite Low
Glutamate 24 30.00 Quite Low
antagonist 78 23.04 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 16 99.00 Very High Very High Very High
Stress 96 74.32 Quite High
INFLAMMATION 64 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Hyperplasia 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ghrelin may also be involved in somatotroph cell differentiation since ghrelin regulates pituitary-specific transcription factor (Pit-1) expression in the rat pituitary [62].
Gene_expression (expression) of Pit-1 in pituitary
1) Confidence 0.19 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0.12
However, ghrelin may also be involved in somatotroph cell differentiation since ghrelin regulates pituitary-specific transcription factor (Pit-1) expression in the rat pituitary [62].
Gene_expression (expression) of pituitary-specific transcription factor in pituitary
2) Confidence 0.19 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0.15
is developmentally regulated in the pituitary and RA is known to activate the GH gene through a RA-responsive element in the GH promoter and in the Pit-1 promoter (781, 782) but to repress the THS?
Gene_expression (promoter) of Pit-1 in Pit associated with rheumatoid arthritis
3) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.56 Pain Relevance 0
We also found that at least part of the action of NGF on lactotroph expansion was through a proliferative effect on lactotroph progenitor cells already expressing Pit-1 but not yet PRL (393).
Gene_expression (expressing) of Pit-1 in Pit associated with nerve growth factor
4) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0.52

General Comments

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