INT18830

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Context Info
Confidence 0.81
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 7.14
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TBXA2R) signal transducer activity (TBXA2R)
Anatomy Link Frequency
platelet 7
epithelium 2
radial artery 2
lung 2
granulocyte 1
TBXA2R (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 1 99.98 Very High Very High Very High
bradykinin 77 99.82 Very High Very High Very High
Serotonin 5 99.80 Very High Very High Very High
aspirin 198 99.58 Very High Very High Very High
Paracetamol 13 98.98 Very High Very High Very High
qutenza 8 98.88 Very High Very High Very High
Morphine 5 98.78 Very High Very High Very High
tetrodotoxin 9 98.72 Very High Very High Very High
Inflammation 71 98.36 Very High Very High Very High
Angina 26 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 10 98.88 Very High Very High Very High
Rheumatoid Arthritis 8 98.88 Very High Very High Very High
Adhesions 114 98.40 Very High Very High Very High
INFLAMMATION 100 98.36 Very High Very High Very High
Increased Venous Pressure Under Development 23 98.36 Very High Very High Very High
Cv General 3 Under Development 19 97.80 Very High Very High Very High
Angina 8 97.76 Very High Very High Very High
Cv Unclassified Under Development 15 97.20 Very High Very High Very High
Death 6 97.16 Very High Very High Very High
Injury 30 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High dose aspirin suppressed platelet thromboxane A2 release to below the detection limit after 10 min. 5.
Localization (release) of thromboxane A2 in platelet associated with aspirin
1) Confidence 0.81 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8504628 Disease Relevance 0.05 Pain Relevance 0.46
The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation.
Localization (release) of thromboxane A2 associated with qutenza and bradykinin
2) Confidence 0.79 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7545124 Disease Relevance 0 Pain Relevance 0.62
Our data suggest that bradykinin contracts human isolated small bronchi through thromboxane A2 release.
Localization (release) of thromboxane A2 associated with bradykinin
3) Confidence 0.79 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7545124 Disease Relevance 0 Pain Relevance 0.70
This study was proposed to clarify whether the early thromboxane A2 release contributed to the ongoing myocardial ischaemia and to determine which metabolites can be attributed to the thromboxane A2 release.
Localization (release) of thromboxane A2 associated with coronary artery disease
4) Confidence 0.73 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.50 Pain Relevance 0.19
Platelet thromboxane A2 release declined gradually after low dose aspirin, reaching a minimum of 93% inhibition after 60 min.
Localization (release) of thromboxane A2 in Platelet associated with aspirin
5) Confidence 0.70 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8504628 Disease Relevance 0.06 Pain Relevance 0.50
This study was proposed to clarify whether the early thromboxane A2 release contributed to the ongoing myocardial ischaemia and to determine which metabolites can be attributed to the thromboxane A2 release.
Spec (whether) Localization (release) of thromboxane A2 associated with coronary artery disease
6) Confidence 0.64 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.45 Pain Relevance 0.19
These flow variations are associated with transient platelet aggregation and dislodgment and the release of selected mediators, including thromboxane A2 and serotonin.
Localization (release) of thromboxane A2 in platelet associated with serotonin
7) Confidence 0.61 Published 1991 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 1987239 Disease Relevance 0.24 Pain Relevance 0.23
The aim of the present study was to investigate if the function of 5-hydroxytryptamine-1B/1D (5-HT1B/1D) receptors in human radial artery (RA) and internal thoracic artery (ITA) can be modified by thromboxane A2 (TXA2) released from the vessel wall in these two arteries that are commonly used in coronary artery bypass grafts.
Localization (released) of thromboxane A2 in radial artery associated with rheumatoid arthritis
8) Confidence 0.61 Published 2000 Journal Gen. Pharmacol. Section Abstract Doc Link 11707315 Disease Relevance 0.19 Pain Relevance 0.32
The aim of the present study was to investigate if the function of 5-hydroxytryptamine-1B/1D (5-HT1B/1D) receptors in human radial artery (RA) and internal thoracic artery (ITA) can be modified by thromboxane A2 (TXA2) released from the vessel wall in these two arteries that are commonly used in coronary artery bypass grafts.
Localization (released) of TXA2 in radial artery associated with rheumatoid arthritis
9) Confidence 0.61 Published 2000 Journal Gen. Pharmacol. Section Abstract Doc Link 11707315 Disease Relevance 0.19 Pain Relevance 0.32
The release of myocardial thromboxane A2 before any lactate production was observed in patients with unstable angina.
Localization (release) of thromboxane A2 associated with angina
10) Confidence 0.56 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.43 Pain Relevance 0.17
They are the result of the mechanical effect of the growing thrombus, which causes intermittent episodes of partial obstruction of the arterial lumen, in association with vasoconstriction at the stenotic site and dependent coronary arterial bed, produced by the cyclic release of platelet derived vasoactive products, namely thromboxane A2 and serotonin.
Localization (release) of thromboxane A2 in platelet associated with increased venous pressure under development, serotonin and thrombosis
11) Confidence 0.52 Published 1994 Journal Rev Port Cardiol Section Abstract Doc Link 7873224 Disease Relevance 0.77 Pain Relevance 0.52
Molecules important for normal physiology, such as vasoactive substance prostacyclin (PGI2) and thromboxane A2 (TXA2), are metabolized in the same system as well.
Localization (metabolized) of TXA2
12) Confidence 0.42 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.65 Pain Relevance 0.23
Molecules important for normal physiology, such as vasoactive substance prostacyclin (PGI2) and thromboxane A2 (TXA2), are metabolized in the same system as well.
Localization (metabolized) of thromboxane A2
13) Confidence 0.42 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.65 Pain Relevance 0.23
Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM.
Localization (release) of thromboxane A2 in lung
14) Confidence 0.32 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12
Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM.
Localization (release) of TXA2 in lung
15) Confidence 0.32 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12
The release of TXA2 from these cells by N-formyl-methionyl-leucyl-phenylalanine or arachidonic acid was not inhibited.
Localization (release) of TXA2
16) Confidence 0.32 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.13 Pain Relevance 0.12
To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A2 by cyclooxygenase in the platelets and the release of ADP from dense platelet granules.
Localization (release) of thromboxane A2 in platelet
17) Confidence 0.26 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.08 Pain Relevance 0.15
Furthermore, we measured the BK-induced release of the prostanoids PGE2, PGI2, and TXA2 from airways with and without epithelium in the absence and presence of indomethacin by radioimmunoassay.
Localization (release) of TXA2 in epithelium associated with bradykinin
18) Confidence 0.21 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0.07 Pain Relevance 0.80
PGE2, PGI2, and TXA2 were released by both intact and epithelium-denuded airways.
Localization (released) of TXA2 in epithelium
19) Confidence 0.21 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0 Pain Relevance 0.69
Both contractile and relaxation responses to BK and the release of the prostanoids PGE2, PGI2, and TXA2 by the airway tissues were largely inhibited by indomethacin, whereas TTX had no effect.
Localization (release) of TXA2 associated with tetrodotoxin and bradykinin
20) Confidence 0.21 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0 Pain Relevance 0.76

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