INT188317

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 12.70
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
liver 3
endothelium 3
platelet 2
ECM 2
cementum 2
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 49 99.68 Very High Very High Very High
fibrosis 96 96.48 Very High Very High Very High
Inflammatory marker 6 92.04 High High
ischemia 23 82.88 Quite High
metalloproteinase 36 82.08 Quite High
Inflammatory response 17 80.24 Quite High
peripheral neuropathy 9 79.16 Quite High
Osteoarthritis 1 73.40 Quite High
Inflammation 93 50.00 Quite Low
Nerve growth factor 2 41.68 Quite Low
Disease Link Frequency Relevance Heat
Injury 288 99.98 Very High Very High Very High
Disease 88 99.98 Very High Very High Very High
Breast Cancer 98 99.60 Very High Very High Very High
Sickle Cell Anemia 63 98.60 Very High Very High Very High
Acid Reflux 6 98.44 Very High Very High Very High
Pulmonary Hypertension 105 98.40 Very High Very High Very High
Metastasis 6 97.76 Very High Very High Very High
Skin Ulcer 122 97.44 Very High Very High Very High
Periodontitis 5 97.04 Very High Very High Very High
Cirrhosis 265 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies stemmed from the observations that most of the cell types entering the wound are capable of synthesizing PDGF and are also activated by PDGF and the hypothesis that exogenous application of PDGF could amplify its proliferative effect through an autocrine feedback loop (Pierce et al 1991).
Positive_regulation (capable) of Gene_expression (synthesizing) of PDGF associated with injury
1) Confidence 0.46 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 1.56 Pain Relevance 0.12
Continued stimulation of these cells after their arrival to the wound leads to endogenous production of PDGF, provisional ECM synthesis, fibroblast proliferation, and collagen production.
Positive_regulation (leads) of Gene_expression (production) of PDGF in ECM associated with injury
2) Confidence 0.46 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.77 Pain Relevance 0
We found that, in vitro, irradiation of fibroblasts and endothelium induced autocrine and paracrine PDGF expression.
Positive_regulation (induced) of Gene_expression (expression) of PDGF in endothelium
3) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.28 Pain Relevance 0.11
In multivariate analyses, higher levels of PDGF and lower levels of VEGF were associated with elevated regurgitation velocity.
Positive_regulation (levels) of Gene_expression (levels) of PDGF associated with acid reflux
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.58 Pain Relevance 0.05
At present, recombinant PDGF is produced by DNA technology via incorporation of the gene for the ?
Positive_regulation (incorporation) of Gene_expression (produced) of recombinant PDGF
5) Confidence 0.20 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.54 Pain Relevance 0
-actin, basic fibroblast growth factor, vascular endothelial growth factor, platelet-derived growth factor (PDGF), PDGF receptors and integrins ?
Positive_regulation (-) of Gene_expression (receptors) of PDGF in platelet
6) Confidence 0.19 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.68 Pain Relevance 0.15
We found that, in vitro, irradiation of fibroblasts and endothelium induced autocrine and paracrine PDGF expression.
Positive_regulation (induced) of in fibroblasts Gene_expression (expression) of PDGF in endothelium
7) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.28 Pain Relevance 0.11
This peculiar effect of HNE and HAKs is transient, with sensitivity to PDGF-BB being recovered within 48 hours and associated with increased expression of PDGF-?
Positive_regulation (increased) of Gene_expression (expression) of PDGF
8) Confidence 0.12 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.07 Pain Relevance 0
Increased expression of PDGF receptors correlates with an increased risk of distant metastasis, decreased response to chemotherapy and reduced overall survival [22,23].
Positive_regulation (Increased) of Gene_expression (expression) of PDGF associated with metastasis
9) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.36 Pain Relevance 0
Likewise poor overall survival rates and low response to chemotherapy are correlated with over-expression of PDGF receptors [23].
Positive_regulation (over) of Gene_expression (expression) of PDGF
10) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.04 Pain Relevance 0
Direct in vivo transfer of PDGF-B stimulated both alveolar bone and cementum regeneration in a rat acute periodontitis model [82].


Positive_regulation (transfer) of Gene_expression (transfer) of PDGF in cementum associated with periodontitis
11) Confidence 0.08 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0.16 Pain Relevance 0
In vivo, uptake was associated with disease-induced expression of the PDGF receptor in liver and kidney.
Positive_regulation (induced) of Gene_expression (expression) of PDGF receptor in liver associated with disease
12) Confidence 0.04 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.74 Pain Relevance 0.13
Moreover, enhanced MAP kinase activities, such as extracellular signal-regulated kinase (ERK) and p38 kinase [35], might play a role in PDGF-induced vascular SMC migration, which is in line with the observation of increased ERK expression in the precapillary arteries of MCT-treated rats (data not shown).
Positive_regulation (role) of Gene_expression (migration) of PDGF
13) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.08 Pain Relevance 0
The MMP expression may be stimulated by growth factors (PDGF, EGF), cytokines, most notably interleukin IL-1?
Positive_regulation (stimulated) of Gene_expression (factors) of PDGF associated with cytokine
14) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.73 Pain Relevance 0.12
Moreover, enhanced MAP kinase activities, such as extracellular signal-regulated kinase (ERK) and p38 kinase [35], might play a role in PDGF-induced vascular SMC migration, which is in line with the observation of increased ERK expression in the precapillary arteries of MCT-treated rats (data not shown).
Positive_regulation (induced) of Gene_expression (migration) of PDGF
15) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.08 Pain Relevance 0
In vivo, uptake was associated with disease-induced expression of the PDGF receptor in liver and kidney.
Positive_regulation (induced) of in kidney Gene_expression (expression) of PDGF receptor in liver associated with disease
16) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.74 Pain Relevance 0.13

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