INT188318

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.00
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (MCPH1) intracellular (MCPH1) microtubule organizing center (MCPH1)
cytoplasm (MCPH1)
Anatomy Link Frequency
bone marrow 1
MCPH1 (Homo sapiens)
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 10 99.54 Very High Very High Very High
antagonist 26 97.60 Very High Very High Very High
metalloproteinase 20 88.52 High High
sSRI 2 85.52 High High
Inflammation 12 82.96 Quite High
fluoxetine 6 77.48 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 370 100.00 Very High Very High Very High
Hypoxia 16 99.04 Very High Very High Very High
Congenital Anomalies 6 97.60 Very High Very High Very High
Body Weight 10 93.20 High High
Hypertrophy 76 89.60 High High
Adhesions 38 85.32 High High
INFLAMMATION 18 82.96 Quite High
Disease 16 69.52 Quite High
Targeted Disruption 2 69.52 Quite High
Injury 6 50.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A serotonin receptor antagonist, MCI-9042, attenuated the development of MCT-induced PAH, suggesting a pivotal role of serotonin in the development of PAH induced by MCT [24].
MCT Positive_regulation (induced) of PAH associated with pulmonary hypertension, antagonist and serotonin
1) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.03 Pain Relevance 0.59
In another study the effect of bone marrow-derived cells on PAH induced by either MCT or exposure to chronic hypoxia in mice was investigated.
MCT Positive_regulation (induced) of PAH in bone marrow associated with pulmonary hypertension and hypoxia
2) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.58 Pain Relevance 0
In addition, MMP 1, an interstitial collagenase, is upregulated in MCT-induced PAH [6].
MCT Positive_regulation (induced) of PAH associated with pulmonary hypertension
3) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.58 Pain Relevance 0.26
Essentially, we found that inhaled tolafentrine reverses hemodynamic abnormalities as well as structural changes, SMC migration and proliferation and matrix remodeling, representing the key features of MCT induced PAH.


MCT Positive_regulation (induced) of PAH associated with pulmonary hypertension and congenital anomalies
4) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.81 Pain Relevance 0

General Comments

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