INT18832

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 7.12
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CASP4) intracellular (CASP4)
Anatomy Link Frequency
plasma 2
granulocytes 1
CASP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.38 Very High Very High Very High
qutenza 46 99.32 Very High Very High Very High
aspirin 105 98.76 Very High Very High Very High
Dynorphin 1 98.40 Very High Very High Very High
Enkephalin 2 98.00 Very High Very High Very High
Inflammation 98 97.98 Very High Very High Very High
cINOD 72 97.92 Very High Very High Very High
Opioid 3 96.14 Very High Very High Very High
dexamethasone 9 90.00 High High
narcan 3 86.56 High High
Disease Link Frequency Relevance Heat
Stress 19 100.00 Very High Very High Very High
Cancer 10 99.32 Very High Very High Very High
Death 19 98.96 Very High Very High Very High
Infection 12 98.48 Very High Very High Very High
INFLAMMATION 125 97.98 Very High Very High Very High
Apoptosis 38 97.76 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.08 Very High Very High Very High
Opportunistic Infections 1 91.20 High High
Fever 4 86.64 High High
Pulmonary Hypertension 1 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, as expected, adverse CV events were associated with an increased Tx-M/PGI-M ratio.
Positive_regulation (increased) of Tx-M
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.39
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of caspase-4 associated with stress and qutenza
2) Confidence 0.33 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.24 Pain Relevance 0.80
In MCF10A cells, capsaicin did not elicit p38 activation and LC3 conversion and caused the sustained activation of caspase-4.
Positive_regulation (activation) of caspase-4 associated with qutenza
3) Confidence 0.33 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.48 Pain Relevance 0.65
We also sought to test three hypotheses: (i) that CV adverse events in ADAPT participants were associated with an increase in the Tx-M/PGI-M ratio, (ii) that use of ASA might ameliorate NSAID-induced changes in urine Tx-M/PGI-M ratio, and (iii) that use of NSAIDs and/or ASA would alter urine or plasma F2-IsoP concentrations.
Positive_regulation (increase) of Tx-M in plasma associated with aspirin and cinod
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.61
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (activated) of caspase-4 associated with stress and qutenza
5) Confidence 0.22 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.22 Pain Relevance 0.78
Autophagy blocking by 3-methyladenine (3MA) or bafilomycin A1 (BaF1) activated caspase-4 and -7 and enhanced cell death.
Positive_regulation (activated) of caspase-4 associated with death
6) Confidence 0.22 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.66 Pain Relevance 0.57
The compound augmented the formation of TxA2 stimulated by the ionophore of divalent cations (A23187).
Positive_regulation (augmented) of TxA2
7) Confidence 0.07 Published 1987 Journal FEBS Lett. Section Abstract Doc Link 3121389 Disease Relevance 0.09 Pain Relevance 0.09
We show that DMC increases intracellular free calcium levels and potently triggers the ESR in various tumor cell lines, as indicated by transient inhibition of protein synthesis, activation of ER stress-associated proteins GRP78/BiP, CHOP/GADD153, and caspase-4, and subsequent tumor cell death.
Positive_regulation (activation) of caspase-4 associated with stress, cancer and death
8) Confidence 0.03 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17431104 Disease Relevance 1.34 Pain Relevance 0.16
None of the opioid peptides tested [(D-Ala2, D-Leu5)-enkephalin (DADL), (D-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) or dynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes.
Positive_regulation (induced) of TxB2 in granulocytes associated with dynorphin, enkephalin, opioid and morphine
9) Confidence 0.02 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 1.06
The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.
Positive_regulation (increased) of caspase 4
10) Confidence 0.02 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.85 Pain Relevance 0
PGE2 is an important anti-inflammatory mediator and, at low concentrations, it acts as a bronchodilator, whereas higher concentrations can lead to bronchoconstriction via the TX receptor.


Positive_regulation (lead) of TX receptor associated with inflammation
11) Confidence 0.01 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.47 Pain Relevance 0.33
Plasma thromboxane B2 (TxB) increased in response to Oxygent HT.
Positive_regulation (increased) of TxB in Plasma
12) Confidence 0.00 Published 1994 Journal Artif Cells Blood Substit Immobil Biotechnol Section Abstract Doc Link 7849964 Disease Relevance 0.72 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox