INT18833

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 32
Disease Relevance 27.61
Pain Relevance 10.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
macrophages 3
blood 2
sputum 1
plasma 1
PGE2 1
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 437 99.96 Very High Very High Very High
antagonist 17 99.96 Very High Very High Very High
dexamethasone 294 99.82 Very High Very High Very High
Osteoarthritis 315 99.56 Very High Very High Very High
Morphine 5 99.38 Very High Very High Very High
Fibrositis 22 99.28 Very High Very High Very High
Dynorphin 1 98.40 Very High Very High Very High
Enkephalin 3 98.00 Very High Very High Very High
Pain 37 97.84 Very High Very High Very High
Opioid 3 96.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 2 100.00 Very High Very High Very High
Pancreatic Cancer 34 99.84 Very High Very High Very High
Occupational Lung Diseases 518 99.76 Very High Very High Very High
Myalgia 18 99.58 Very High Very High Very High
Asthma 1430 99.56 Very High Very High Very High
Osteoarthritis 318 99.56 Very High Very High Very High
Injury 3 99.56 Very High Very High Very High
Sclerosis 6 99.32 Very High Very High Very High
Sleep Disorders 30 99.28 Very High Very High Very High
Hypersensitivity 19 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTB4 levels are increased on needle trauma in patients with myalgia.
Positive_regulation (increased) of LTB4 associated with injury and myalgia
1) Confidence 0.69 Published 2001 Journal Acta Odontol. Scand. Section Abstract Doc Link 11831483 Disease Relevance 1.21 Pain Relevance 0.89
Intramuscular levels were found in all groups, with significantly higher levels of LTB4 in the patients with fibromyalgia, in whom PGE2 was positively correlated to muscular pain.
Positive_regulation (levels) of LTB4 in PGE2 associated with pain and fibrositis
2) Confidence 0.60 Published 2001 Journal Acta Odontol. Scand. Section Abstract Doc Link 11831483 Disease Relevance 1.36 Pain Relevance 0.94
Although the data suggest a trend for elevated LTB4 levels, statistical analysis did not support this conclusion.
Positive_regulation (elevated) of LTB4
3) Confidence 0.56 Published 2001 Journal Am J Rhinol Section Abstract Doc Link 11258655 Disease Relevance 0.72 Pain Relevance 0.08
It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.
Positive_regulation (increase) of LTB4
4) Confidence 0.31 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3037972 Disease Relevance 0.17 Pain Relevance 0.07
However are in contrast with other reports showing increased levels of LTB4 and BLT receptors in allergic versus non-allergic nasal polyp patients [10].
Positive_regulation (increased) of LTB4 in nasal associated with hypersensitivity and nasal polyps
5) Confidence 0.29 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.35 Pain Relevance 0.12
LTB4 on proliferation and MAP kinase activation in pancreatic cancer
Positive_regulation (activation) of LTB4 associated with pancreatic cancer
6) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.69 Pain Relevance 0.25
LTB4: leukotriene B4
Positive_regulation (leukotriene) of LTB4
7) Confidence 0.27 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.63 Pain Relevance 0.03
In the patients with local myalgia the plasma level of LTB4 also increased, and this increase was associated with a decrease of pain and masseter tenderness.
Positive_regulation (increased) of LTB4 in plasma associated with pain and myalgia
8) Confidence 0.18 Published 2002 Journal Acta Odontol. Scand. Section Abstract Doc Link 11902610 Disease Relevance 1.08 Pain Relevance 0.83
In addition, the masseter muscle level of LTB4 increases in patients with fibromyalgia and local myalgia.
Positive_regulation (increases) of LTB4 in masseter associated with fibrositis and myalgia
9) Confidence 0.16 Published 2002 Journal Acta Odontol. Scand. Section Abstract Doc Link 11902610 Disease Relevance 0.94 Pain Relevance 0.64
Addition of calcium ionophore, A23187, to human blood increased basal immunoreactive LTB4 levels from less than 100pg ml-1 to 259 +/- 23ng ml-1 (mean +/- SEM, n = 16).
Positive_regulation (increased) of LTB4 in blood
10) Confidence 0.08 Published 1986 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3012587 Disease Relevance 0 Pain Relevance 0.12
In non-severe asthmatics, both LPS and LPS plus dexamethasone gave an increased LTB4/LXA4 ratio, but only in severe asthmatics was the increase induced by LPS and dexamethasone significantly greater than that induced by LPS alone (p < 0.05) (Figure 5).
Positive_regulation (increased) of LTB4 associated with occupational lung diseases and dexamethasone
11) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.97 Pain Relevance 0.35
LPS induced LTB4 generation in all three groups (p < 0.05), but the increase in LTB4 in severe asthma patients was 5-fold greater than in non-severe asthmatics (p < 0.05; Figure 2B).


Positive_regulation (increase) of LTB4 associated with asthma and occupational lung diseases
12) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.81 Pain Relevance 0.16
Previously, no differences in CS sensitivity of AMs in terms of calcium ionophore induced LTB4 from asthmatics as compared to non-asthmatic macrophages have been reported[29].
Positive_regulation (induced) of LTB4 in macrophages associated with asthma, corticosteroid and occupational lung diseases
13) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.46 Pain Relevance 0.58
This differential response of AMs from severe asthmatics vis-a-vis LTB4 and LXA4 and the effect of corticosteroids (increased LTB4 in response to LPS and impaired CS suppression of the rise in LTB4 vs. little change in LXA4 in response to LPS and unimpaired CS suppression of LXA4 levels) may contribute to persistent airway neutrophilic inflammation since LXA4 can inhibit LTB4-induced chemotaxis, adhesion and transmigration[17].
Positive_regulation (increased) of LTB4 associated with corticosteroid, inflammation, occupational lung diseases and adhesions
14) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.19 Pain Relevance 0.61
In addition, similar findings have been reported in airway fluids for the levels of these lipid mediators; thus, an increase in LTB4 levels was found in the supernatant of induced sputum of severe asthma patients compared to non-severe asthma.
Positive_regulation (increase) of LTB4 in sputum associated with asthma
15) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.27 Pain Relevance 0.03
In addition, LTB4/LXA4 ratios after LPS and dexamethasone were significantly greater in severe asthmatics compared to non-severe asthmatics (p < 0.05) as a result of both an increase in LTB4 and a decrease in LXA4 compared to normal subjects.


Positive_regulation (increase) of LTB4 associated with occupational lung diseases and dexamethasone
16) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.29 Pain Relevance 0.28
Only half of the patients with severe asthma in this study were on oral corticosteroid therapy and there was no significant differences in terms of LPS-induced LTB4 or LXA4 or of dexamethasone-induced suppression between macrophages of severe asthma patients who were on prednisolone versus those not on prednisolone.
Neg (no) Positive_regulation (induced) of LTB4 in macrophages associated with asthma, corticosteroid and dexamethasone
17) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.73 Pain Relevance 0.30
Similarly, in the non-severe asthma group, there was no difference in terms of LPS-induced LTB4 or LXA4 or of dexamethasone-induced suppression between macrophages of non-severe asthma patients who were on daily inhaled corticosteroids versus those not on inhaled corticosteroids.
Positive_regulation (induced) of LTB4 in macrophages associated with asthma, corticosteroid and dexamethasone
18) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.90 Pain Relevance 0.30
More specific approaches are to give antioxidants, inhibitors of inducible nitric oxide synthase, and leukotriene B4 receptor antagonists.
Positive_regulation (inducible) of leukotriene B4 receptor associated with antagonist
19) Confidence 0.03 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 17305523 Disease Relevance 1.07 Pain Relevance 0.37
None of the opioid peptides tested [(D-Ala2, D-Leu5)-enkephalin (DADL), (D-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) or dynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes.
Positive_regulation (induced) of LTB4 in granulocytes associated with dynorphin, enkephalin, opioid and morphine
20) Confidence 0.02 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 1.06

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