INT188344

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 5.97
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
T cells 16
natural Tregs 4
iTreg 2
Treg 2
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 12 99.96 Very High Very High Very High
rheumatoid arthritis 220 93.12 High High
tolerance 163 89.56 High High
cytokine 179 87.24 High High
Inflammation 198 86.84 High High
Central nervous system 97 86.44 High High
Multiple sclerosis 68 81.36 Quite High
Inflammatory response 14 71.76 Quite High
Arthritis 66 70.72 Quite High
palliative 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 97 96.60 Very High Very High Very High
Lymphatic System Cancer 1 94.96 High High
Multiple Sclerosis 326 94.60 High High
Rheumatoid Arthritis 220 93.12 High High
Diabetes Mellitus 56 88.96 High High
Graft Vs Host Disease 7 87.28 High High
Autoimmune Disease 111 87.20 High High
INFLAMMATION 205 86.84 High High
Organ Transplantation 12 86.60 High High
Immunization 96 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular co-staining for FOXP3 showed significant IFN?
Positive_regulation (staining) of Gene_expression (showed) of FOXP3
1) Confidence 0.36 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.36 Pain Relevance 0.08
cells can be converted to the CD25+ Treg phenotype following in vitro stimulation, with associated acquisition of Treg-like function, and induction of FoxP3 expression (22–24).
Spec (like) Positive_regulation (induction) of Gene_expression (expression) of FoxP3 in Treg
2) Confidence 0.35 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.22 Pain Relevance 0.04
Although the role of FoxP3 in humans is more complex (24), lentiviral transduction of FoxP3 has recently allowed generation of stable human Tregs (23).
Positive_regulation (transduction) of Gene_expression (transduction) of FoxP3
3) Confidence 0.35 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.22 Pain Relevance 0.14
Through transduction with FoxP3, large numbers of Tregs (denoted here FoxP3-Tregs), whose properties resemble those of natural Tregs, can be generated for experimental purposes (22,23).
Positive_regulation (generated) of Gene_expression (transduction) of FoxP3 in natural Tregs
4) Confidence 0.35 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.30 Pain Relevance 0.12
All three cell populations showed a phenotypic pattern characteristic of Tregs, including expression of high levels of FoxP3, CD25 and CD62L (Figure 1A–C).
Positive_regulation (levels) of Gene_expression (expression) of FoxP3
5) Confidence 0.33 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0 Pain Relevance 0
Through transduction with FoxP3, large numbers of Tregs (denoted here FoxP3-Tregs), whose properties resemble those of natural Tregs, can be generated for experimental purposes (22,23).
Positive_regulation (generated) of Gene_expression (transduction) of FoxP3 in natural Tregs
6) Confidence 0.31 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.30 Pain Relevance 0.12
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (elevated) of Gene_expression (expression) of FoxP3 in T cells
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (mean) of Gene_expression (expression) of FoxP3 in T cells
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (mean) of Gene_expression (expression) of FoxP3 in T cells
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (elevated) of Gene_expression (expression) of FoxP3 in T cells
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.66 Pain Relevance 0.18
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (elevated) of Gene_expression (expression) of FoxP3 in T cells
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.33 Pain Relevance 0.19
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (mean) of Gene_expression (expression) of FoxP3 in T cells
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.32 Pain Relevance 0.18
The authors showed that infliximab treatment induced differentiation of a Treg cell population expressing FoxP3 and low levels of CD62L through conversion of CD4+CD25- T cells.
Positive_regulation (induced) of Gene_expression (expressing) of FoxP3 in T cells associated with infliximab
13) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.47 Pain Relevance 0.44
Interestingly, treatment with anti-TNF antibody (infliximab) increases FoxP3 expression in CD4+CD25high Treg cells and restores their suppressive function [73,74].
Positive_regulation (increases) of Gene_expression (expression) of FoxP3 associated with infliximab
14) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.61 Pain Relevance 0.46
mediated induction of Foxp3 expression in naïve T cells [32].
Positive_regulation (induction) of Gene_expression (expression) of Foxp3 in T cells
15) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0.06
induces Foxp3 expression and iTreg cell differentiation from CD4+CD25?
Positive_regulation (induces) of Gene_expression (expression) of Foxp3 in iTreg
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.08 Pain Relevance 0

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