INT188347

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 4.53
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Hspd1) cytosol (Hspd1) mitochondrion (Hspd1)
extracellular space (Hspd1) Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
B16-F1 3
epithelial cells 1
Hspd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 62 99.20 Very High Very High Very High
chemokine 30 98.76 Very High Very High Very High
tolerance 55 94.76 High High
agonist 12 90.96 High High
palliative 3 50.00 Quite Low
Inflammation 34 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 13 100.00 Very High Very High Very High
Cancer 503 99.84 Very High Very High Very High
Experimental Melanoma 30 92.92 High High
Metastasis 276 90.68 High High
Lymphatic System Cancer 1 83.16 Quite High
Brain Tumor 6 76.32 Quite High
Death 45 75.44 Quite High
Lewis Lung Carcinoma 6 66.64 Quite High
Yersinia Infection 6 59.92 Quite High
Mucositis 74 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These, identified by microarray include, PI3-K, JAK2, JAK3, STAT3, Grb2, IRS, and PLCgamma1, Rho-GTPase activating protein (RAB35), kinases (MEK kinase 1 and 4, PKC, MLCK, cyclin G-associated kinase, EphA1, JNK kinase, MAP kinase 1), phosphatases (meprin, PTPK, protein phosphatase 2 subunit), and heat shock proteins (Hsp60 precursor), as well as SOCS (25).
Localization (precursor) of Hsp60 associated with shock
1) Confidence 0.41 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.10
Firstly, the highly metastatic B16 cells not only release higher level of HSP60, but also have a higher-level expression of TLR2 and basal activity of Stat3 compared to low metastatic B16-F1 cells.
Localization (release) of HSP60 in B16-F1
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.75 Pain Relevance 0.05
The alveolar epithelial cells did not release HSP60 under the same conditions as the B16 cells did (data not shown).
Neg (not) Localization (release) of HSP60 in epithelial cells
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.54 Pain Relevance 0.03
TLR2 activity mediated HSP60-stimulated release of the suppressive cytokines, chemokines, and the expression of CCR8 in B16 cells (Fig.
Localization (release) of HSP60 associated with chemokine and cytokine
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.16 Pain Relevance 0.24
We found that the high-metastatic B16 cells released much more HSP60 than the low-metastatic B16-F1 cells cultured without or with lower serum concentrations (Fig.
Localization (released) of HSP60 in B16-F1
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.47 Pain Relevance 0.04
Importantly, heat shock protein 60 released by tumor cells caused a persistent activation of TLR2 and was critical in the constitutive activation of transcription factor Stat3, leading to the release of immunosuppressive cytokines and chemokines.
Localization (released) of heat shock protein 60 associated with chemokine, cancer, shock and cytokine
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2716531 Disease Relevance 1.24 Pain Relevance 0.13
High metastatic B16 cells released more heat shock protein 60 than poor metastatic B16-F1 cells.
Localization (released) of heat shock protein 60 in B16-F1 associated with shock
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2716531 Disease Relevance 1.19 Pain Relevance 0.12

General Comments

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